concept

CEREBRAL AMYLOID ANGIOPATHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CEREBRAL AMYLOID ANGIOPATHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections

0Hypotheses

1Analyses

43Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CEREBRAL AMYLOID ANGIOPATHY
Key Genes/Proteins	AMYLOID, APOE, TREM2
Related Diseases	AMYLOID PLAQUES, DEMENTIA

Pathway Diagram

graph TD
    CEREBRAL_AMYLOID_ANGIOPATHY["CEREBRAL AMYLOID ANGIOPATHY"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"causes"| Intracerebral_Haemorrhage["Intracerebral Haemorrhage"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"contributes to"| Cerebral_Small_Vessel_Disease["Cerebral Small Vessel Disease"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"causes"| Cognitive_Decline["Cognitive Decline"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"causes"| Intracerebral_Hemorrhage["Intracerebral Hemorrhage"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"causes"| vascular_permeability["vascular permeability"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"causes"| Amyloid["Amyloid"]
    CEREBRAL_AMYLOID_ANGIOPATHY -->|"causes"| Complement["Complement"]
    Amyloid_Beta["Amyloid-Beta"] -->|"causes"| CEREBRAL_AMYLOID_ANGIOPATHY
    Neuroinflammation["Neuroinflammation"] -->|"involved_in"| CEREBRAL_AMYLOID_ANGIOPATHY
    BETA_AMYLOID["BETA-AMYLOID"] -->|"involved_in"| CEREBRAL_AMYLOID_ANGIOPATHY
    Complement_System["Complement System"] -->|"contributes to"| CEREBRAL_AMYLOID_ANGIOPATHY
    APOE4["APOE4"] -->|"contributes to"| CEREBRAL_AMYLOID_ANGIOPATHY
    CAA_Related_Inflammation["CAA-Related Inflammation"] -.biomarker for.-> CEREBRAL_AMYLOID_ANGIOPATHY
    Amyloid_beta["Amyloid-beta"] -->|"causes"| CEREBRAL_AMYLOID_ANGIOPATHY
    Complement_Activation["Complement Activation"] -->|"contributes to"| CEREBRAL_AMYLOID_ANGIOPATHY

Outgoing (43)

Target	Relation	Type	Str
Intracerebral Haemorrhage	causes	phenotype	0.90
Cerebral Small Vessel Disease	contributes_to	disease	0.90
Cognitive Decline	causes	phenotype	0.85
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
Alzheimer's Disease	associated_with	disease	0.85
Intracerebral Hemorrhage	causes	disease	0.80
microglia	affects	cell_type	0.70
tau pathology	causes	mechanism	0.70
blood-brain barrier	affects	brain_region	0.70
CSF p-tau217 normalization	prevents	process	0.70
vascular permeability	causes	process	0.70
Cognitive Decline	contributes_to	phenotype	0.70
astrocytes	affects	cell_type	0.60
macrophages	affects	cell_type	0.60
complement cascade	involves	pathway	0.60
lipid metabolism	involves	pathway	0.60
Amyloid	causes	pathway	0.55
Microglia	associated_with	cell_type	0.55
Astrocyte	causes	cell_type	0.55
Microglia	causes	cell_type	0.55
Macrophage	causes	cell_type	0.55
Complement	causes	pathway	0.55
Immune Response	activates	pathway	0.55
Macrophage	activates	cell_type	0.55
Cerebrovascular	associated_with	pathway	0.55
Innate Immunity	regulates	pathway	0.55
Blood-Brain Barrier	contributes_to	pathway	0.55
Epigenetic	regulates	pathway	0.55
Complement System	regulates	pathway	0.55
Stem Cell	regulates	cell_type	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Endothelial	therapeutic_target	cell_type	0.55
Amyloid	associated_with	pathway	0.55
Complement	contributes_to	pathway	0.55
Blood-Brain Barrier	causes	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
White Matter	associated_with	brain_region	0.50
Cortex	associated_with	brain_region	0.50
BASAL GANGLIA	associated_with	brain_region	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
CAUDATE NUCLEUS	associated_with	brain_region	0.45
CHOROID PLEXUS	associated_with	brain_region	0.45
LECANEMAB	associated_with	drug	0.45

Incoming (92)

Source	Relation	Type	Str
39308178	led to decrease in	paper	0.90
APOE	associated_with	gene	0.90
Neuroinflammation	involved_in	process	0.90
BETA-AMYLOID	involved_in	protein	0.90
NEUROINFLAMMATION	associated_with	process	0.90
Complement System	contributes_to	pathway	0.85
APOE ε4 Allele	associated_with	biomarker	0.85
Amyloid-beta	causes	protein	0.80
MICROGLIA	associated_with	cell_type	0.80
CAA-Related Inflammation	biomarker_for	process	0.80
Aria	associated_with	phenotype	0.80
APOE ε4	associated_with	gene	0.80
APOC2	biomarker_for	unknown	0.80
APOE4	contributes_to	gene	0.80
ASTROCYTES	involved_in	cell_type	0.80
Complement Activation	involved_in	process	0.75
Matrix Metalloproteinases	involved_in	enzyme	0.75
Complement Activation	contributes_to	pathway	0.75
Apolipoprotein E	associated_with	protein	0.70
anti-Aβ immunotherapy	activates	drug	0.70
perivascular macrophages	regulates	cell_type	0.70
APOE	interacts_with	gene	0.70
APOE	increases_risk	gene	0.70
ALZHEIMER	causes	gene	0.65
LOX	expressed_in	gene	0.65
JUN	expressed_in	gene	0.65
ASTROCYTES	causes	gene	0.65
ALZHEIMER'S DISEASE	causes	gene	0.65
STROKE	associated_with	gene	0.65
DEMENTIA	associated_with	gene	0.65
DEMENTIA	therapeutic_target	gene	0.65
ALZHEIMER	therapeutic_target	gene	0.65
INFLAMMATION	associated_with	gene	0.65
COMPLEMENT	causes	gene	0.65
RNA	activates	gene	0.65
DSP	activates	gene	0.65
AMYLOID	activates	gene	0.65
ALZHEIMER	activates	gene	0.65
AGING	associated_with	gene	0.65
NEURODEGENERATION	activates	gene	0.65
ALZHEIMER DISEASE	associated_with	gene	0.65
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	gene	0.65
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.65
AGING	causes	gene	0.65
INFLAMMATION	causes	gene	0.65
DEPRESSION	causes	gene	0.65
STROKE	causes	gene	0.65
AMYLOID	causes	gene	0.65
TMEM106B	expressed_in	gene	0.65
ALZHEIMER'S DISEASE	expressed_in	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.585

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can CSF p-tau217 normalization serve as a reliable surrogate endpoint for determ

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning CEREBRAL AMYLOID ANGIOPATHY in their description or question text

No additional research found