concept

ITGB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITGB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	ITGB1
Key Genes/Proteins	Actin, Akt, AKT, AND, App, Bdnf
Related Diseases	Als, ALS, Cancer, Carcinoma
Related Pathways	blood-brain barrier, Cholesterol

Wiki Pages (1)

Knowledge base pages for this entity

Integrin Beta-1 (ITGB1) Protein

protein · 565 words

→

Pathway Diagram

graph TD
    ITGB1["ITGB1"]
    ITGB1 -->|"activates"| ERK["ERK"]
    ITGB1 -->|"binds"| SIGLEC10["SIGLEC10"]
    ITGB1 -->|"activates"| Tumor["Tumor"]
    ITGB1 -->|"activates"| Glioblastoma["Glioblastoma"]
    ITGB1 -->|"activates"| Als["Als"]
    ITGB1 -->|"activates"| Cancer["Cancer"]
    ITGB1 -->|"activates"| Fibrosis["Fibrosis"]
    SPP1["SPP1"] -->|"binds_to"| ITGB1
    LOX["LOX"] -->|"activates"| ITGB1
    GBM["GBM"] -->|"activates"| ITGB1
    NF__B["NF-KappaB"] -->|"activates"| ITGB1
    NRP1["NRP1"] -->|"activates"| ITGB1
    HMGCR["HMGCR"] -->|"activates"| ITGB1
    VEGFA["VEGFA"] -->|"interacts"| ITGB1

Outgoing (65)

Target	Relation	Type	Str
ERK	activates	protein	0.88
SIGLEC10	binds	gene	0.80
Psoriasis	associated_with	disease	0.80
NF-kB signaling	participates_in	pathway	0.70
Depression	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Fibrosis	activates	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	activates	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cirrhosis	activates	disease	0.65
GLIOBLASTOMA	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
GLI1	activates	gene	0.60
HMGCR	activates	gene	0.60
Bdnf	associated_with	protein	0.60
BDNF	associated_with	gene	0.60
App	associated_with	protein	0.60
STAT3	activates	gene	0.60
CHI3L1	activates	gene	0.60
AND	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
NF-KB	activates	gene	0.60
Fibroblast	activates	cell_type	0.60
Nf-Kb	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
IL-6	activates	gene	0.60
Stem Cell	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
Actin	activates	protein	0.60
NRP1	activates	gene	0.60
blood-brain barrier	participates_in	pathway	0.60
Notch signaling	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
senescence	participates_in	pathway	0.60
Collagen	activates	protein	0.60
T cells	expressed_in	cell_type	0.60
LINGO3	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
Dna Methylation	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
AND	associated_with	gene	0.60
SKA2	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60

Incoming (29)

Source	Relation	Type	Str
SPP1	binds_to	protein	0.93
LOX	activates	protein	0.70
NRP1	activates	gene	0.60
HMGCR	activates	gene	0.60
VEGFA	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
GPX4	targets	gene	0.60
CHI3L1	activates	gene	0.60
LINGO3	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
NF-KB	activates	gene	0.60
RNA	activates	gene	0.60
BDNF	interacts_with	gene	0.60
FKBP5	interacts_with	gene	0.60
GBM	activates	gene	0.60
SPP1	activates	gene	0.60
NF-ΚB	activates	gene	0.60
DEPRESSION	associated_with	gene	0.60
SKA2	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
DNA	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
GENES	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
AKT	activates	gene	0.60
MYC	activates	gene	0.60
C-MYC	activates	gene	0.60
STAT3	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ITGB1 in their description or question text

No additional research found