gene 2,049 words KG: CXCL1
Contents

CXCL1

🧬 Gene Info
Gene SymbolCXCL1
AliasesC-X-C motif chemokine ligand 1 (GROα)
Protein TypeReceptor
Primary Expressionblood-brain barrier
Amino Acids107 aa
PathwaysChemoresistance, Cholesterol, Tnf Signaling, Toll-Like Receptor, Tumor Microenvironment
Ensembl IDENSG00000163425
GeneCardsCXCL1
Human Protein AtlasCXCL1
Associated DiseasesAlzheimer, Inflammation, Ms, neurodegeneration, Neuroinflammation, Pancreatic Cancer
Known Drugs/Compoundsrapamycin
InteractionsAkt, AKT, AND, APOE, App, ASTROCYTES
KG Connections466 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (20)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (1)

Electroacupuncture ST37 treatment for DSS-induced colitis in
validation · proposed · Score: 0.95

See Also (8)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: protects_against
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: protects_against
ANG — Angiogenin
gene · KG edge: associated_with
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CXCL2 inhibits CXCL1
IL6 inhibits CXCL1
ATF4 therapeutic_target CXCL1
PPP1R15A therapeutic_target CXCL1
IL12B inhibits CXCL1
XBP1 therapeutic_target CXCL1
CXCL1 therapeutic_target DDIT3
CXCL1 inhibits CLDN5
CXCL1 therapeutic_target HSPA5
CXCL1 inhibits OCLN

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