gene

GBA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

14Outgoing

9Incoming

0Experiments

0Debates

Summary

Gene encoding a lysosomal glucosidase involved in glycolipid metabolism, with implications for Parkinson's disease and Gaucher disease.

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🧬 Gene Info

Gene Symbol	GBA3
Full Name	Glucosidase Beta 3
Chromosome	4p15.2
Protein Type	Hydrolase
Function	encodes a member of the glycoside hydrolase family, specifically a lysosomal glucocerebrosidase enzyme.
Amino Acids	556 aa
UniProt ID	Q9Y5K2
NCBI Gene ID	57733
GeneCards	GBA3
Human Protein Atlas	GBA3
Associated Diseases	Hypertension, Ms
Interactions	COMT, CYP2C18, CYP3A5, SLC22A2, UGT3A1
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GBA3 — AlphaFold Q9Y5K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GBA3 — Glucosidase Beta 3

gene · 916 words

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Pathway Diagram

graph TD
    GBA3["GBA3"]
    Hypertension{"Hypertension"}
    GBA3 -->|"associated with"| Hypertension
    Ms{"Ms"}
    GBA3 -->|"associated with"| Ms
    COMT["COMT"]
    GBA3 -->|"associated with"| COMT
    SLC22A2["SLC22A2"]
    GBA3 -->|"associated with"| SLC22A2
    INSULIN_RESISTANCE["INSULIN RESISTANCE"]
    GBA3 -->|"associated with"| INSULIN_RESISTANCE
    neurodegeneration["neurodegeneration"]
    GBA3 -->|"implicated in"| neurodegeneration
    COMT -->|"associated with"| GBA3
    SLC22A2 -->|"associated with"| GBA3
    AND["AND"]
    AND -->|"associated with"| GBA3
    style GBA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Metabolite Levels	regulates	phenotype	0.80
Hypertension	associated_with	disease	0.65
Ms	associated_with	disease	0.65
UGT3A1	associated_with	gene	0.60
CYP2C18	associated_with	gene	0.60
App	associated_with	protein	0.60
UGT3A1	interacts_with	gene	0.60
COMT	associated_with	gene	0.60
SLC22A2	associated_with	gene	0.60
INSULIN RESISTANCE	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
Insulin	associated_with	protein	0.60
SLC22A2	interacts_with	gene	0.50
COMT	interacts_with	protein	0.50

Incoming (9)

Source	Relation	Type	Str
INSULIN RESISTANCE	associated_with	gene	0.60
CYP2C18	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
UGT3A1	associated_with	gene	0.60
CYP2C18	interacts_with	gene	0.60
CYP3A5	interacts_with	gene	0.60
COMT	associated_with	gene	0.60
SLC22A2	associated_with	gene	0.60
COMT	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GBA3 in their description or question text

No additional research found