Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYP2C18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CYP2C18 |
| Key Genes/Proteins | App, COMT, CYP3A5, GBA3, Insulin, INSULIN RESISTANCE |
| Related Diseases | Hypertension |
graph TD
CYP2C18["CYP2C18"]
CYP2C18 -->|"involved_in"| Metabolic_Processes["Metabolic Processes"]
CYP2C18 ---|"associated"| Hypertension["Hypertension"]
CYP2C18 ---|"associated"| CYP3A5["CYP3A5"]
CYP2C18 ---|"associated"| GBA3["GBA3"]
CYP2C18 ---|"associated"| SLC22A2["SLC22A2"]
CYP2C18 ---|"associated"| COMT["COMT"]
INSULIN_RESISTANCE["INSULIN RESISTANCE"] ---|"associated"| CYP2C18
UGT3A1["UGT3A1"] ---|"associated"| CYP2C18
CYP3A5 ---|"associated"| CYP2C18
GBA3 ---|"associated"| CYP2C18
COMT ---|"associated"| CYP2C18| Target | Relation | Type | Str |
|---|---|---|---|
| Metabolic Processes | involved_in | process | 0.80 |
| Hypertension | associated_with | disease | 0.65 |
| GBA3 | associated_with | gene | 0.60 |
| SLC22A2 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| UGT3A1 | associated_with | gene | 0.60 |
| CYP3A5 | associated_with | gene | 0.60 |
| INSULIN RESISTANCE | associated_with | gene | 0.60 |
| App | associated_with | protein | 0.60 |
| CYP3A5 | interacts_with | gene | 0.60 |
| GBA3 | interacts_with | gene | 0.60 |
| SLC22A2 | interacts_with | gene | 0.60 |
| UGT3A1 | interacts_with | gene | 0.60 |
| Insulin | associated_with | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CYP2C18 in their description or question text
No additional research found