gene

SLC22A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC22A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

14Outgoing

10Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	SLC22A2
Full Name	Solute Carrier Family 22 Member 2 (OCT2)
Chromosome	6q26
Protein Type	Transporter
Function	is a polyspecific transmembrane transporter that mediates the Na⁺-independent transport of organic cations across cell membranes.
Primary Expression	monoaminergic and cholinergic axon terminals[@araya2016], where it contributes to the clearance of dopamine, norepinephrine, and other neuroactive cat
Molecular Weight	63 kDa
Amino Acids	556 aa
Exons	11
UniProt ID	O15228
NCBI Gene ID	6580
Ensembl ID	ENSG00000112406
OMIM	603731
GeneCards	SLC22A2
Human Protein Atlas	SLC22A2
Associated Diseases	Hypertension, Ms
Interactions	COMT, CYP2C18, CYP3A5, GBA3, UGT3A1
KG Connections	24 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC22A2 — AlphaFold O15228 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

slc22a2

gene · 1811 words

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Pathway Diagram

graph TD
    SLC22A2["SLC22A2"]
    Hypertension{"Hypertension"}
    SLC22A2 -->|"associated with"| Hypertension
    Ms{"Ms"}
    SLC22A2 -->|"associated with"| Ms
    GBA3["GBA3"]
    SLC22A2 -->|"associated with"| GBA3
    INSULIN_RESISTANCE["INSULIN RESISTANCE"]
    SLC22A2 -->|"associated with"| INSULIN_RESISTANCE
    AND["AND"]
    SLC22A2 -->|"associated with"| AND
    COMT["COMT"]
    SLC22A2 -->|"associated with"| COMT
    neurodegeneration["neurodegeneration"]
    SLC22A2 -->|"implicated in"| neurodegeneration
    GBA3 -->|"associated with"| SLC22A2
    COMT -->|"associated with"| SLC22A2
    style SLC22A2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Metabolite Levels	regulates	phenotype	0.85
Hypertension	associated_with	disease	0.65
Ms	associated_with	disease	0.65
CYP2C18	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
Insulin	associated_with	protein	0.60
COMT	associated_with	gene	0.60
App	associated_with	protein	0.60
AND	associated_with	gene	0.60
UGT3A1	associated_with	gene	0.60
UGT3A1	interacts_with	gene	0.60
GBA3	associated_with	gene	0.60
INSULIN RESISTANCE	associated_with	gene	0.60
COMT	interacts_with	protein	0.50

Incoming (10)

Source	Relation	Type	Str
INSULIN RESISTANCE	associated_with	gene	0.60
CYP2C18	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
GBA3	associated_with	gene	0.60
COMT	associated_with	gene	0.60
COMT	interacts_with	gene	0.60
CYP2C18	interacts_with	gene	0.60
CYP3A5	interacts_with	gene	0.60
UGT3A1	associated_with	gene	0.60
GBA3	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC22A2 in their description or question text

No additional research found