gene 815 words KG: CDK4
Contents

CDK4 Gene

🧬 Gene Info
Gene SymbolCDK4
Full NameCyclin-Dependent Kinase 4
Chromosome12q14.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight34 kDa
Amino Acids303 aa
Exons8
PathwaysAkt, Dna Methylation, Epigenetic, Pi3K
UniProt IDP11802
NCBI Gene ID1019
Ensembl IDENSG00000136492
GeneCardsCDK4
Human Protein AtlasCDK4
Associated DiseasesAls, Cancer, Carcinoma, glioblastoma, Melanoma
InteractionsACTB, AKT, AND, APOPTOSIS, ARAF, ATF4
KG Connections406 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
PARP1 Inhibition Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACTB Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: therapeutic_target
ARAF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

RANK activates CDK4
RANKL activates CDK4
CDK4 associated_with CASP3
CDK4 regulates PI3K
CDK4 associated_with ESR1
CDK4 associated_with CHEK1
CDK4 associated_with MTOR
CDK4 associated_with PIK3CA
CDK4 associated_with GSK3B
CDK4 regulates AKT

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