protein

CASPASE-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for Caspase-3 Protein

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🔬 Protein Info

Gene Symbol	CASPASE
Chromosome	4q35.1.
GeneCards	CASPASE
Human Protein Atlas	CASPASE
Associated Diseases	Fibrosis, Cancer, Als, Aging, Lymphoma, Neurodegeneration
Interactions	AKT, ALZHEIMER, AMYLOID, BCL-2, BCL2, BDNF
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: CASPASE-3 — AlphaFold P42574 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-3 (CASP3)

protein · 1510 words

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Pathway Diagram

graph TD
    CASPASE_3["CASPASE-3"]
    GSDME["GSDME"]
    CASPASE_3 -->|"cleaves"| GSDME
    AMYLOID["AMYLOID"]
    CASPASE_3 -->|"activates"| AMYLOID
    HES1["HES1"]
    CASPASE_3 -->|"activates"| HES1
    CD68["CD68"]
    CASPASE_3 -->|"expressed in"| CD68
    cancer["cancer"]
    CASPASE_3 -->|"expressed in"| cancer
    TUMOR["TUMOR"]
    CASPASE_3 -->|"expressed in"| TUMOR
    Macrophage["Macrophage"]
    CASPASE_3 -->|"expressed in"| Macrophage
    MACROPHAGES["MACROPHAGES"]
    CASPASE_3 -->|"expressed in"| MACROPHAGES
    apoptosis["apoptosis"]
    CASPASE_3 -->|"inhibits"| apoptosis
    cancer["cancer"]
    CASPASE_3 -->|"activates"| cancer
    Pyroptosis["Pyroptosis"]
    CASPASE_3 -->|"activates"| Pyroptosis
    BREAST_CANCER["BREAST CANCER"]
    CASPASE_3 -->|"activates"| BREAST_CANCER
    GASDERMIN_E["GASDERMIN E"]
    CASPASE_3 -->|"activates"| GASDERMIN_E
    TUMOR["TUMOR"]
    CASPASE_3 -->|"activates"| TUMOR
    CELL_DEATH["CELL DEATH"]
    CASPASE_3 -->|"activates"| CELL_DEATH
    METASTASIS["METASTASIS"]
    CASPASE_3 -->|"activates"| METASTASIS
    GASDERMIN["GASDERMIN"]
    CASPASE_3 -->|"activates"| GASDERMIN
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    CASPASE_3 -->|"activates"| Reactive_Oxygen_Species
    NADPH["NADPH"]
    CASPASE_3 -->|"activates"| NADPH
    PUMA["PUMA"]
    CASPASE_3 -->|"activates"| PUMA
    FIS1["FIS1"]
    CASPASE_3 -->|"activates"| FIS1
    BECLIN1["BECLIN1"]
    CASPASE_3 -->|"activates"| BECLIN1
    HO_1["HO-1"]
    CASPASE_3 -->|"activates"| HO_1
    inflammation["inflammation"]
    CASPASE_3 -->|"activates"| inflammation
    apoptosis["apoptosis"]
    CASPASE_3 -->|"activates"| apoptosis
    oxidative_stress["oxidative stress"]
    CASPASE_3 -->|"activates"| oxidative_stress
    BCL_2["BCL-2"]
    CASPASE_3 -->|"activates"| BCL_2
    Toll_Like_Receptor["Toll-Like Receptor"]
    CASPASE_3 -->|"activates"| Toll_Like_Receptor
    Lymphoma["Lymphoma"]
    CASPASE_3 -->|"activates"| Lymphoma
    ENDOTHELIAL["ENDOTHELIAL"]
    CASPASE_3 -->|"activates"| ENDOTHELIAL

Outgoing (84)

Target	Relation	Type	Str
Apoptosis	mediates	process	0.95
apoptosis	activates	phenotype	0.90
neuronal apoptosis	promotes	process	0.90
tau cleavage	activates	process	0.90
ATP11C	inhibits	protein	0.70
Glaucoma	associated_with	disease	0.70
Apoptosis	activates	pathway	0.70
Apoptosis	associated_with	pathway	0.70
CD68	expressed_in	protein	0.50
cancer	expressed_in	disease	0.50
TUMOR	expressed_in	disease	0.50
Macrophage	expressed_in	cell_type	0.50
MACROPHAGES	expressed_in	concept	0.50
apoptosis	inhibits	process	0.50
CASPASE-9	associated_with	protein	0.50
NEURONS	associated_with	concept	0.50
NLRP1	interacts_with	protein	0.50
BCL-2	interacts_with	protein	0.50
CYTOKINES	interacts_with	concept	0.50
Lymphoma	interacts_with	disease	0.50
RAPAMYCIN	interacts_with	concept	0.50
NEURONS	regulates	concept	0.50
CASPASE-9	activates	protein	0.50
IL-1Β	activates	protein	0.50
Hippocampus	activates	entity	0.50
IL-6	expressed_in	protein	0.50
CASPASE-9	expressed_in	protein	0.50
IL-1Β	expressed_in	protein	0.50
NF-ΚB P65	expressed_in	protein	0.50
NF-κB	expressed_in	concept	0.50
BCL-2	expressed_in	protein	0.50
TNF-α	expressed_in	concept	0.50
ALZHEIMER	inhibits	gene	0.50
oxidative stress	inhibits	phenotype	0.50
Alzheimer'S Disease	inhibits	disease	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
Neuron	activates	cell_type	0.50
Spinal Cord	activates	cell_type	0.50
NEURONS	activates	concept	0.50
Neuron	associated_with	cell_type	0.50
MOTOR NEURONS	associated_with	concept	0.50
MOTOR NEURON	associated_with	concept	0.50
NADPH	activates	protein	0.50
PUMA	activates	protein	0.50
FIS1	activates	protein	0.50
BECLIN1	activates	gene	0.50
HO-1	activates	protein	0.50
inflammation	activates	pathway	0.50
apoptosis	activates	process	0.50

Incoming (51)

Source	Relation	Type	Str
41104344	decreased	paper	0.90
R-phycoerythrin	associated_with	drug	0.90
PRKCD	activates	gene	0.90
JAK2/STAT3 Signaling Pathway	downregulates	pathway	0.87
APAF1	activates	protein	0.80
JAK-STAT	activates	pathway	0.80
R-PE	activates	drug	0.80
DHT	regulates	compound	0.80
Apoptosis	associated_with	pathway	0.70
RKIP	inhibits	protein	0.70
BCL2	inhibits	protein	0.70
ALZHEIMER	activates	gene	0.50
PRESENILIN	activates	protein	0.50
ANXA1	expressed_in	protein	0.50
CASP3	expressed_in	gene	0.50
GLAUCOMA	associated_with	gene	0.50
Pi3K	interacts_with	pathway	0.50
BDNF	interacts_with	gene	0.50
TRKB	interacts_with	gene	0.50
mTOR	interacts_with	entity	0.50
BCL2	interacts_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
MITOCHONDRIA	regulates	cell_type	0.50
GFAP	expressed_in	gene	0.50
CYTC	expressed_in	gene	0.50
NMNAT1	inhibits	gene	0.50
GSDME	activates	gene	0.50
STAT3	activates	gene	0.50
PSEN1	activates	gene	0.50
HES1	activates	gene	0.50
CATALASE	activates	protein	0.50
Neurodegeneration	regulates	disease	0.50
AKT	activates	protein	0.50
Neurodegeneration	activates	disease	0.50
mTOR	inhibits	entity	0.50
JAK2	activates	gene	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
TAAR1	activates	gene	0.50
TRAF6	activates	gene	0.50
mTOR	activates	entity	0.50
SIGMAR1	activates	gene	0.50
MYD88	activates	gene	0.50
VEGF	activates	gene	0.50
CHOP	activates	gene	0.50
BCL2	activates	gene	0.50
NRF2	activates	gene	0.50
CREB	activates	protein	0.50
S100A9	activates	gene	0.50
CHMP4B	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does tau aggregation specifically cause PS externalization in vesicles independe

neurodegeneration | 2026-04-11 | 0 hypotheses

Does tau aggregation specifically cause PS externalization in living cells versu

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate identified a critical gap in understanding whether PS exposure is tau

closed · Rounds: 4 · Score: 0.44 · 2026-04-21

The debate revealed a fundamental gap in understanding whether tau pathology dir

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CASPASE-3 in their description or question text

No additional research found