protein 1,510 words KG: CASPASE3
Contents

Caspase-3 (CASP3)

🔬 Protein Info
Gene SymbolCASP3
Full NameCaspase-3 (CASP3)
AliasesCASPASE3
Chromosome4q35.1.
Protein FamilyCysteine-aspartate protease (caspase) family
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCytoplasm, mitochondria (activated)
Molecular Weight32 kDa (zymogen); 17 + 12 kDa (active heterodimer)
PathwaysApoptosis
UniProt IDP42574
GeneCardsCASP3
Human Protein AtlasCASP3
Associated DiseasesLymphoma
InteractionsAGING, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND
KG Connections218 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (5)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: activates
AKT1 Gene
gene · KG edge: activates
APAF1 Gene
gene · KG edge: regulates
BAX Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CASP3 encodes CASPASE3
EHMT2 associated_with CASPASE3
CASPASE3 associated_with BAX
CASPASE3 inhibits JUN
CASPASE3 associated_with CASPASE8
CASPASE3 associated_with BCL2
CASPASE3 associated_with FOXO1
CASPASE8 associated_with CASPASE3
BAX associated_with CASPASE3
JUN inhibits CASPASE3

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.