protein

GASDERMIN E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASDERMIN E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

9Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for Gasdermin E Protein

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🔬 Protein Info

Gene Symbol	GASDERMIN E
Molecular Weight	55.4 kDa
Amino Acids	496 aa
Pathways	Pyroptosis
Interactions	CASPASE-3, GASDERMIN, GSDME
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GASDERMIN_E("GASDERMIN E")
    cancer{"cancer"}
    GASDERMIN_E -->|"activates"| cancer
    TUMOR{"TUMOR"}
    GASDERMIN_E -->|"activates"| TUMOR
    CELL_DEATH["CELL DEATH"]
    GASDERMIN_E -->|"activates"| CELL_DEATH
    BREAST_CANCER{"BREAST CANCER"}
    GASDERMIN_E -->|"activates"| BREAST_CANCER
    METASTASIS["METASTASIS"]
    GASDERMIN_E -->|"activates"| METASTASIS
    GASDERMIN["GASDERMIN"]
    GASDERMIN_E -->|"activates"| GASDERMIN
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    GASDERMIN_E -->|"activates"| Reactive_Oxygen_Species
    apoptosis["apoptosis"]
    GASDERMIN_E -->|"expressed_in"| apoptosis
    Pyroptosis(["Pyroptosis"])
    GASDERMIN_E -->|"expressed_in"| Pyroptosis
    GASDERMIN_E -->|"expressed_in"| GASDERMIN
    GSDME["GSDME"]
    GSDME -->|"activates"| GASDERMIN_E
    CASPASE_3("CASPASE-3")
    CASPASE_3 -->|"activates"| GASDERMIN_E
    GSDME -->|"expressed_in"| GASDERMIN_E

Outgoing (9)

Target	Relation	Type	Str
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
CELL DEATH	activates	concept	0.50
BREAST CANCER	activates	disease	0.50
GASDERMIN	activates	gene	0.50
Reactive Oxygen Species	activates	process	0.50
apoptosis	expressed_in	process	0.50
Pyroptosis	expressed_in	pathway	0.50
GASDERMIN	expressed_in	gene	0.50

Incoming (3)

Source	Relation	Type	Str
GSDME	activates	gene	0.50
CASPASE-3	activates	protein	0.50
GSDME	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GASDERMIN E in their description or question text

No additional research found