gene

SETD1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SETD1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

18Outgoing

11Incoming

0Experiments

0Debates

Summary

setd1a

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SETD1A
Full Name	SET Domain Containing 1A, Histone Lysine Methyltransferase
Chromosome	16p11.2
Protein Type	Transferase
Function	encodes a histone H3 lysine 4 (H3K4) methyltransferase that is the catalytic subunit of the SETD1A/COMPASS complex.
UniProt ID	O15047
Ensembl ID	ENSG00000099381
OMIM	611052
GeneCards	SETD1A
Human Protein Atlas	SETD1A
Associated Diseases	schizophrenia
Interactions	AND, ANK3, CACNA1G, GENES, KMT2A, KMT2B
KG Connections	29 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SETD1A — AlphaFold O15047 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

setd1a

gene · 2794 words

→

Pathway Diagram

graph TD
    SETD1A["SETD1A"]
    Schizophrenia{"Schizophrenia"}
    SETD1A -.->|"inhibits"| Schizophrenia
    Autism{"Autism"}
    SETD1A -.->|"inhibits"| Autism
    ANK3(["ANK3"])
    SETD1A -.->|"inhibits"| ANK3
    GAIN(["GAIN"])
    SETD1A -->|"expressed_in"| GAIN
    RNA(["RNA"])
    SETD1A -->|"expressed_in"| RNA
    KMT2B(["KMT2B"])
    SETD1A -.->|"inhibits"| KMT2B
    KMT2A(["KMT2A"])
    KMT2A -.->|"inhibits"| SETD1A
    SHANK3(["SHANK3"])
    SHANK3 -.->|"inhibits"| SETD1A
    GENES(["GENES"])
    GENES -.->|"inhibits"| SETD1A
    CACNA1G(["CACNA1G"])
    CACNA1G -.->|"inhibits"| SETD1A
    style SETD1A fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (18)

Target	Relation	Type	Str
Schizophrenia	inhibits	disease	0.65
Autism	inhibits	disease	0.65
SHANK3	inhibits	gene	0.60
KMT2D	inhibits	gene	0.60
CACNA1G	inhibits	gene	0.60
KMT2A	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
schizophrenia	interacts_with	disease	0.60
schizophrenia	associated_with	disease	0.60
ANK3	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
schizophrenia	regulates	disease	0.60
KMT2B	inhibits	gene	0.60
Ras	inhibits	protein	0.60
AND	inhibits	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
synaptic plasticity	participates_in	pathway	0.60
GENE EXPRESSION	inhibits	concept	0.50

Incoming (11)

Source	Relation	Type	Str
ANK3	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
KMT2A	inhibits	gene	0.60
SHANK3	inhibits	gene	0.60
CACNA1G	inhibits	gene	0.60
GENES	inhibits	gene	0.60
KMT2B	inhibits	gene	0.60
KMT2D	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
AUTISM	inhibits	disease	0.50
SCHIZOPHRENIA	inhibits	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SETD1A in their description or question text

No additional research found