gene

KMT2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KMT2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections
0Hypotheses
0Analyses
38Outgoing
20Incoming
0Experiments
0Debates

Summary

KMT2B — lysine methyltransferase 2B

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🧬 Gene Info
Gene SymbolKMT2B
Full NameMLL2 (Mixed-Lineage Leukemia 2) / MLL4
Aliaseslysine methyltransferase 2B
Protein FamilySET1/MLL COMPASS Family
Protein TypeTransferase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionbrain tissue
Subcellular LocalizationNucleus
Molecular Weight445 kDa
PathwaysFMN-induced Anti-inflammatory Effect
UniProt IDQ9UMN6
GeneCardsKMT2B
Human Protein AtlasKMT2B
Alzheimer's DiseaseAltered expression and function contributes to epigenetic dysregulation of neuronal survival genes
Parkinson's DiseaseMay affect dopaminergic neuron survival through transcriptional mechanisms
Associated DiseasesALS, Alzheimer
InteractionsAND, ANK3, CACNA1G, GENES, KMT2A, KMT2D
KG Connections58 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: KMT2B — AlphaFold Q9UMN6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KMT2B — lysine methyltransferase 2B

gene · 578 words

MLL2/MLL4 Histone H3K4 Methyltransferase (KMT2B)

protein · 515 words

Pathway Diagram

graph TD
    KMT2B["KMT2B"]
    RFK["RFK"]
    FMN_induced_Anti_inflammatory_["FMN-induced Anti-inflammatory Effect"]
    Alzheimer["Alzheimer"]
    Neuroinflammation["Neuroinflammation"]
    ALS["ALS"]
    Inflammation["Inflammation"]
    Als["Als"]
    Schizophrenia["Schizophrenia"]
    Autism["Autism"]
    TNFR1["TNFR1"]
    NF__B["NF-KappaB"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    AND["AND"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MICROGLIA["MICROGLIA"]
    Oxidative_Stress["Oxidative Stress"]
    Synaptic_Plasticity["Synaptic Plasticity"]
    Nf__b["Nf-Kappab"]
    Microglia["Microglia"]
    KMT2B -->|"regulates"| RFK
    KMT2B -->|"regulates"| FMN_induced_Anti_inflammatory_
    KMT2B -->|"protects_agains"| Alzheimer
    KMT2B -->|"protects_agains"| Neuroinflammation
    KMT2B -->|"protects_agains"| ALS
    KMT2B -->|"protects_agains"| Inflammation
    KMT2B -->|"protects_agains"| Als
    KMT2B -.->|"inhibits"| Schizophrenia
    KMT2B -.->|"inhibits"| Autism
    KMT2B -.->|"inhibits"| TNFR1
    KMT2B -.->|"inhibits"| NF__B
    KMT2B -->|"protects_agains"| OXIDATIVE_STRESS
    KMT2B -.->|"inhibits"| AND
    KMT2B -->|"protects_agains"| ALZHEIMER_S_DISEASE
    KMT2B -.->|"inhibits"| RFK
    KMT2B -->|"protects_agains"| MICROGLIA
    KMT2B -->|"protects_agains"| Oxidative_Stress
    KMT2B -->|"protects_agains"| Synaptic_Plasticity
    KMT2B -.->|"inhibits"| Nf__b
    KMT2B -->|"protects_agains"| Microglia
    style KMT2B fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (38)

TargetRelationTypeStr
RFKregulatesgene0.90
FMN-induced Anti-inflammatory Effectregulatesmechanism0.85
Alzheimerprotects_againstdisease0.65
Neuroinflammationprotects_againstdisease0.65
ALSprotects_againstdisease0.65

Incoming (20)

SourceRelationTypeStr
ALZHEIMER'S DISEASEprotects_againstgene0.60
OXIDATIVE STRESSprotects_againstgene0.60
NF-ΚBinhibitsgene0.60
KMT2Ainhibitsgene0.60
SHANK3inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KMT2B in their description or question text

No additional research found