gene 683 words KG: C1QB
Contents

C1QB — Complement Component 1Q Beta

🧬 Gene Info
Gene SymbolC1QB
Full NameComplement Component 1Q Subunit Beta
Chromosome1p36.12.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe liver as the main source of circulating C1q
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsAIF1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections248 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Complement C1q Mimetic Decoy Therapy
Score: 0.69
...
Score: 0.68
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61

Related Analyses (10)

Are interneuron oscillation deficits compensatory responses
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

Single-cell RNA sequencing analysis of human atherosclerotic
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (6)

AIF1 Gene
gene · KG edge: associated_with
C1QA Gene
gene · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

C1QB interacts_with MET
C1QB interacts_with C1Q
CTSH interacts_with C1QB
C1QB activates SOD1
C1QB interacts_with HSP27
CCR1 regulates C1QB
MRC1 regulates C1QB
C1QB regulates CD38
C1QB regulates CD163
C1QB regulates CXCL10

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