protein 1,611 words KG: C1QBPROTEIN
Contents

C1QB Protein — Complement Component 1 Q

🔬 Protein Info
Gene SymbolC1QB
Full NameC1QB — Complement Component 1Q Beta
AliasesC1QBPROTEIN
Chromosome1p36.12.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe liver as the main source of circulating C1q
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsAIF1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections248 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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UniProtWikipedia

Related Hypotheses (11)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
...
Score: 0.68
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Complement C1q Subtype Switching
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (12)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (8)

Single-cell RNA sequencing analysis of human atherosclerotic
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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