Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic pruning dysregulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Complement-Mediated Synaptic Pruning Dysregulation | 0.612 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| C1q neutralization experiment | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| scRNA-seq analysis of human atherosclerotic plaques | exploratory | Atherosclerosis | 0.900 | 0.00 | human atherosclerotic plaque s | proposed | N/A |
| Sevoflurane-induced neurotoxicity (SIN) model in rats | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| Machine learning-based identification of C1Q hub genes | exploratory | Atherosclerosis | 0.900 | 0.00 | Human bulk RNA sequencing data | proposed | N/A |
| Gene expression validation in apoE-/- mice | validation | Atherosclerosis | 0.850 | 0.00 | apoE-/- mice | proposed | N/A |
| ox-LDL treatment of RAW264.7 macrophages | exploratory | Atherosclerosis | 0.850 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| Validation of hub genes in ox-LDL treated RAW264.7 macrophages | exploratory | Atherosclerosis | 0.800 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| Validation of hub genes in apoE-/- atherosclerotic mice | validation | Atherosclerosis | 0.800 | 0.00 | apoE-/- mice | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| Early complement genes are associated with visual system degeneration in multipl [PMID:31289819] | Fitzgerald KC, Kim K, Smith MD, Aston SA | Brain | 2019 | 1 |
| Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964] | Righes Marafiga J, Vu T, Bowlus J, Barab | Progress in neurobiology | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | Geroscience | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | GeroScience | 2026 | 0 |
| Sex-Specific Molecular Architecture of Microglia-Mediated Neuronal Pruning Acros [PMID:41324815] | Sanfilippo C, Castrogiovanni P, Imbesi R | Molecular neurobiology | 2025 | 0 |
| Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649] | Griggs M, Daylor V, Petrucci T, Weintrau | ImmunoHorizons | 2025 | 0 |
| The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007] | Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ, | Journal of neuroinflammation | 2024 | 0 |
| Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. [PMID:35990663] | ["Feng C", "Shan M", "Xia Y", "Zheng Z", | Frontiers in immunology | 2022 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217] | Figueroa CA, Aguilera A, Chakraborty B, | Journal of the American Medica | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient [PMID:34161779] | Lee E, Kang C, Purhonen P, Hebert H, Bou | Journal of molecular biology | 2021 | 0 |
| Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. [PMID:32866962] | Zhang J, Velmeshev D, Hashimoto K, Huang | Nature | 2020 | 0 |
| GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secon [PMID:33147455] | ["Sterling J", "Adetunji M", "Guttha S", | Cell reports | 2020 | 0 |
| Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury. [PMID:32579912] | ["Guttenplan K", "Stafford B", "El-Danaf | Cell reports | 2020 | 0 |
| Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia v [PMID:27114033] | Lui H, Zhang J, Makinson SR, Cahill MK, | Cell | 2016 | 0 |
| Differential Effects of C1qa Ablation on Glaucomatous Damage in Two Sexes in DBA [PMID:26544197] | ["Kumari R", "Astafurov K", "Genis A", " | PloS one | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning synaptic pruning dysregulation in their description or question text
No additional research found