gene

BNIP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BNIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1260Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

BNIP3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 615 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BNIP3
Full Name	BCL2 Interacting Protein 3
Chromosome	10q26.3
Function	is a pro-apoptotic BH3-only protein that plays a dual role in regulating both apoptosis and mitophagy.
Primary Expression	Ubiquitous; high expression in brain, heart, and skeletal muscle
Pathways	Apoptosis, Autophagy, Chaperone, Histone Modification, Lipid Metabolism
UniProt ID	Q12986
NCBI Gene ID	664
Ensembl ID	ENSG00000176171
OMIM	604488
GeneCards	BNIP3
Human Protein Atlas	BNIP3
Associated Diseases	AD, ALI, Als, Alzheimer, brain ischemia
Known Drugs/Compounds	dimethyl fumarate
Interactions	ABCD3, ACETYL-COA, Actin, ADORA2A, AGING, ALS
KG Connections	1257 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BNIP3 — AlphaFold Q12986 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    BNIP3(["BNIP3"])
    Mitophagy("Mitophagy")
    MITOPHAGY(["MITOPHAGY"])
    Autophagy["Autophagy"]
    Als["Als"]
    Ischemia["Ischemia"]
    mitophagy("mitophagy")
    Programmed_Mitophagy("Programmed Mitophagy")
    AUTOPHAGY(["AUTOPHAGY"])
    MITOCHONDRIA(["MITOCHONDRIA"])
    NIX(["NIX"])
    LC3B(["LC3B"])

    BNIP3 -->|"activates"| Mitophagy
    BNIP3 -->|"regulates"| Mitophagy
    MITOPHAGY -->|"regulates"| BNIP3
    MITOPHAGY -->|"activates"| BNIP3
    BNIP3 -->|"activates"| Autophagy
    BNIP3 -->|"activates"| Als
    BNIP3 -->|"regulates"| Ischemia
    BNIP3 -->|"participates in"| mitophagy
    BNIP3 -->|"activates"| mitophagy
    BNIP3 -->|"mediates"| Programmed_Mitophagy
    BNIP3 -->|"activates"| AUTOPHAGY
    BNIP3 -->|"activates"| MITOCHONDRIA
    BNIP3 -->|"regulates"| NIX
    BNIP3 -->|"interacts with"| LC3B
    BNIP3 -->|"involved in"| Mitophagy

    style BNIP3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (926)

Target	Relation	Type	Str
BNIP3	encodes	protein	0.00
Mitophagy	activates	pathway	1.00
Mitophagy	regulates	pathway	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	0.95
Mitophagy	mediates	process	0.95
Ischemia	regulates	disease	0.95
programmed mitophagy	regulates	process	0.90
Programmed Mitophagy	mediates	process	0.90
mitophagy	activates	phenotype	0.90
mitophagy	participates_in	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
MITOCHONDRIA	activates	gene	0.90
NIX	regulates	gene	0.90
AUTOPHAGY	activates	gene	0.90
MITOPHAGY	mediates	process	0.85
WIPI-ATG13 complex	interacts_with	protein	0.80
autophagy	activates	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
Mitophagy	associated_with	process	0.80
LC3B	interacts_with	protein	0.80
MITOPHAGY	associated_with	process	0.80
Apoptosis	activates	pathway	0.80
GENES	activates	gene	0.80
Inflammation	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Als	regulates	disease	0.75
Cancer	regulates	disease	0.75
Ischemia	activates	disease	0.75
Cancer	inhibits	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
CANCER	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
MITOCHONDRIA	regulates	gene	0.70
CANCER	inhibits	gene	0.70
PARKIN	regulates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
Mitophagy	biomarker_for	pathway	0.70
Autophagy	regulates	pathway	0.70
P62	regulates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
Apoptosis	expressed_in	pathway	0.70
APOPTOSIS	expressed_in	gene	0.70
ATG7	activates	gene	0.70
AD	associated_with	disease	0.70
CANCER	regulates	gene	0.70
LC3	activates	gene	0.70
PARKIN	activates	gene	0.70

Incoming (334)

Source	Relation	Type	Str
BNIP3	encodes	gene	0.00
MITOPHAGY	regulates	gene	1.00
MITOPHAGY	activates	gene	1.00
Copper	downregulates	compound	0.95
h-2a4e4ad2	targets_gene	hypothesis	0.90
SIRT1	upregulates	protein	0.85
NFKB	regulates	protein	0.85
Srt2104	upregulates	drug	0.80
FOXO3	regulates	protein	0.80
HIF1A	activates	protein	0.80
NLRP3 inhibition	contributes_to	phenotype	0.80
FOXO	activates	protein	0.80
HIF1	activates	protein	0.80
APOPTOSIS	activates	gene	0.80
ATG	regulates	gene	0.70
ischemia	regulates	process	0.70
PINK1	regulates	gene	0.70
MITOPHAGY	contributes_to	gene	0.70
SIRT1	regulates	gene	0.70
PINK1	activates	gene	0.70
NIX	regulates	gene	0.70
GABARAPL2	activates	gene	0.60
BNIP3L	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
GABARAP	activates	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
NRF2	regulates	gene	0.60
EIF2S1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
FUNDC1	regulates	gene	0.60
BCL2L13	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BCL2	activates	gene	0.60
DDIT3	interacts_with	gene	0.60
ULK1	activates	gene	0.60
PARKIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does tau aggregation specifically cause PS externalization in living cells versu

neurodegeneration | 2026-04-10 | 0 hypotheses

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning BNIP3 in their description or question text

No additional research found

BNIP3

Understanding Entity Pages

Summary

Wiki Pages (4)

BNIP3 Gene

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

BNIP3L Protein

BNIP3 Protein