gene 1,168 words KG: BID
Contents

BID — BH3 Interacting Domain Death Agonist

🧬 Gene Info
Gene SymbolBID
Full NameBH3 Interacting Domain Death Agonist
Chromosome22q11.21
Protein FamilyBCL2 family, BH3-only proteins
Functionis a relatively inactive cytosolic protein.
Molecular Weight22 kDa
Amino Acids195 aa
PathwaysApoptosis, Stem Cell
UniProt IDP55957
NCBI Gene ID637
Ensembl IDENSG00000105619
OMIM603678
GeneCardsBID
Human Protein AtlasBID
N-terminal regionContains caspase-8 cleavage sites (D75, D81)
Associated DiseasesAging, Als, Alzheimer, Inflammation, Neurodegeneration
InteractionsAKT, AND, APOPTOSIS, AUTOPHAGY, BAD, BAX
KG Connections355 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77

Related Analyses (8)

Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (19)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Regulated Necrosis Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Stress Granule Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40
Cholinergic System Dysfunction in DLB — Mechanisms and Thera
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: causes
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: therapeutic_target
ATM Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

LAMP2 associated_with BID
TFRC associated_with BID
PPP1CB associated_with BID
TLR2 therapeutic_target BID
MTOR therapeutic_target BID
BID associated_with BAD
BID associated_with BAK1
BID associated_with BAX
BID activates MTOR
PLA2G6 therapeutic_target BID

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