pathway

oxidative stress response

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about oxidative stress response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1143Connections

2Hypotheses

0Analyses

16Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	oxidative stress response
Key Genes/Proteins	AADC, ABCA1, ABCA4, ABCA7, ABCB1, ABCD3
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| pyroptosis["pyroptosis"]
    style pyroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| necroptosis["necroptosis"]
    style necroptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| ER_stress["ER stress"]
    style ER_stress fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| protein_misfolding["protein misfolding"]
    style protein_misfolding fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| amyloid_aggregation["amyloid aggregation"]
    style amyloid_aggregation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Microglia["Microglia"] -->|"involved in"| oxidative_stress_response["oxidative stress response"]
    style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    OPTN["OPTN"] -->|"promotes"| oxidative_stress_response["oxidative stress response"]
    style OPTN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NRF2["NRF2"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    style NRF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LDL["LDL"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    style LDL fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style oxidative_stress_response fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (16)

Target	Relation	Type	Str
ferroptosis	mediates	process	0.90
necroptosis	mediates	process	0.90
pyroptosis	mediates	process	0.90
protein misfolding	mediates	process	0.80
neural stem cells	active_in	cell_type	0.80
astrocytes	active_in	cell_type	0.80
ER stress	mediates	process	0.80
amyloid aggregation	mediates	process	0.80
phagocytosis	mediates	process	0.70
microglia	active_in	cell_type	0.70
neurons	active_in	cell_type	0.70
unfolded protein response	crosstalk_with	pathway	0.60
oligodendrocytes	active_in	cell_type	0.60
ubiquitin-proteasome	crosstalk_with	pathway	0.60
tau phosphorylation	mediates	process	0.60
axonal transport	mediates	process	0.60

Incoming (1127)

Source	Relation	Type	Str
Microglia	involved_in	cell_type	0.91
OPTN	promotes	protein	0.90
PS1	participates_in	gene	0.90
CHCHD2	participates_in	gene	0.90
OPTN	participates_in	gene	0.90
ACTB	participates_in	gene	0.90
NLRP3	participates_in	gene	0.90
NLR	participates_in	gene	0.90
TNF	participates_in	gene	0.90
GFP	participates_in	gene	0.90
SNCA	participates_in	gene	0.90
ULK1	participates_in	gene	0.90
JNK	participates_in	gene	0.90
ERK	participates_in	gene	0.90
IL6	participates_in	gene	0.90
MTOR	participates_in	gene	0.90
BECN1	participates_in	gene	0.90
LDL	participates_in	gene	0.90
neurodegeneration	involves	disease	0.90
GBA	participates_in	gene	0.90
DRP1	participates_in	gene	0.90
HIF	participates_in	gene	0.90
frontotemporal dementia	involves	disease	0.90
PINK1	participates_in	gene	0.90
ATG	participates_in	gene	0.90
MAP1LC3B	participates_in	gene	0.90
ATG5	participates_in	gene	0.90
LOX	participates_in	gene	0.90
MAP1LC3	participates_in	gene	0.90
LC3	participates_in	gene	0.90
SQSTM1	participates_in	gene	0.90
ATP	participates_in	gene	0.90
FUS	participates_in	gene	0.90
AMPK	participates_in	gene	0.90
GBM	participates_in	gene	0.90
ASC	participates_in	gene	0.90
BDNF	participates_in	gene	0.90
C3	participates_in	gene	0.90
GFAP	participates_in	gene	0.90
SIRT1	participates_in	gene	0.90
TH	participates_in	gene	0.90
APP	participates_in	gene	0.90
autism spectrum disorder	involves	disease	0.90
NRF2	participates_in	gene	0.90
GSH	participates_in	gene	0.90
glioblastoma	involves	disease	0.90
GPX4	participates_in	gene	0.90
ACSL4	participates_in	gene	0.90
SLC7A11	participates_in	gene	0.90
epilepsy	involves	disease	0.90

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Multiplexed Base Editing for Simultaneous Neuroprotective Ge	0.704	neurodegeneration	CRISPR-based therapeutic approaches for
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo	0.638	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning oxidative stress response in their description or question text

No additional research found