| Gene Symbol | BACH1 |
| Full Name | BTB Domain and CNC Homolog 1 |
| Chromosome | 21q21.3 |
| Function | encodes a transcriptional repressor that competes with NRF2 for binding to antioxidant response elements (AREs) in the promoters of cytoprotective genes. |
| Primary Expression | Ubiquitous, high in brain, liver, spleen |
| Pathways | Akt, Apoptosis, Autophagy, Chaperone, Complement |
| UniProt ID | O14867 |
| NCBI Gene ID | 571 |
| Ensembl ID | ENSG00000156273 |
| OMIM | 602751 |
| GeneCards | BACH1 |
| Human Protein Atlas | BACH1 |
| BTB/POZ domain (residues 1-128) | Broad-complex, Tramtrack, Bric-à-brac domain mediating homodimerization and transcriptional repression; recruits corepressor complexes (NCoR, SMRT) |
| CNC-bZIP domain (residues 558-625) | Cap'n'collar basic leucine zipper domain for DNA binding; heterodimerizes with small Maf proteins (MafF, MafG, MafK) |
| CP motifs (6 total) | Cysteine-Proline heme-binding motifs distributed throughout the protein (CP1-CP6); heme binding at CP3-CP6 triggers nuclear export |
| Interactions | AKT, AND, ANTIOXIDANT GENES, APOPTOSIS, ASTROCYTE, CANCER |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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