concept

B CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

538Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

B CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with GLIOBLASTOMA, LYMPHOMA, TUMOR. Connected to 30 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	B CELL
Key Genes/Proteins	AMPK, AQP4, BCL2
Related Diseases	CANCER

Pathway Diagram

graph TD
    B_CELL["B CELL"]
    TCR["TCR"] -->|"expressed in"| B_CELL
    CD40["CD40"] -->|"expressed in"| B_CELL
    CANCER["CANCER"] -->|"expressed in"| B_CELL
    AQP4["AQP4"] -->|"expressed in"| B_CELL
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_CELL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| B_CELL
    CD19["CD19"] -->|"expressed in"| B_CELL
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| B_CELL
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"expressed in"| B_CELL
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| B_CELL

Outgoing (128)

Target	Relation	Type	Str
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.90
ST6Gal1	expressed_in	enzyme	0.90
Igg	expressed_in	protein	0.90
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.90
Aqp4-Igg	associated_with	biomarker	0.88
Neuromyelitis optica spectrum disorder activity	biomarker_for	disease	0.80
P53	inhibits	gene	0.65
LYMPHOMA	reduces	disease	0.65
CANCER	inhibits	disease	0.65
NEUTROPHIL	increases	cell_type	0.65
LYMPHOMA	causes	disease	0.65
BCL2	regulates	gene	0.65
IL-6	inhibits	gene	0.65
MYC	activates	gene	0.60
STING	causes	gene	0.60
T CELLS	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
MACROPHAGE	regulates	cell_type	0.60
T CELL	activates	cell_type	0.60
NEURON	activates	cell_type	0.60
GFAP	activates	gene	0.60
CHAT	activates	gene	0.60
LYMPHOMA	inhibits	disease	0.60
MONOCYTE	promotes	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
TUMOR	inhibits	disease	0.60
PERICYTE	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
NEUTROPHILS	activates	concept	0.50
B CELLS	activates	concept	0.50
B CELLS	interacts_with	concept	0.50
ENDOTHELIAL	co_discussed	entity	0.50
DENDRITIC CELLS	activates	concept	0.50
MONOCYTE	activates	concept	0.50
OCLN	co_discussed	entity	0.50
Microrna	regulates	pathway	0.50
MACROPHAGES	activates	concept	0.50
DNA DAMAGE	regulates	concept	0.50
B CELLS	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
FUT8	activates	concept	0.50
MACROPHAGE	co_discussed	entity	0.50
Dna Damage Response	regulates	pathway	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
T CELLS	activates	concept	0.50
Immunotherapy	activates	process	0.50
ST6GAL1	activates	concept	0.50
FUT8	associated_with	concept	0.50

Incoming (410)

Source	Relation	Type	Str
Inebilizumab	downregulates	drug	0.90
AMPK	activates	gene	0.65
DR5	therapeutic_target	gene	0.60
TCR	activates	gene	0.60
TRAIL	therapeutic_target	gene	0.60
LRP1	activates	gene	0.60
CARD8	associated_with	gene	0.60
FOXO3	protects_against	gene	0.60
TLR	therapeutic_target	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
IL-1	associated_with	gene	0.60
CCL20	activates	gene	0.60
ALS	activates	gene	0.60
GSDMD	associated_with	gene	0.60
OCLN	activates	gene	0.60
SIRT1	protects_against	gene	0.60
LC3B	protects_against	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
RNA	associated_with	gene	0.60
ROS	activates	gene	0.60
P53	therapeutic_target	gene	0.60
NLRP1	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
C1QA	activates	gene	0.60
DEMENTIA	activates	gene	0.60
TDP-43	activates	gene	0.60
IL-1	activates	gene	0.60
NLRP3	associated_with	gene	0.60
AKT	activates	gene	0.60
RNA	regulates	gene	0.60
AMPK	protects_against	gene	0.60
AQP4	activates	gene	0.60
AQP4	inhibits	gene	0.60
BCL-2	therapeutic_target	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
IFN	therapeutic_target	gene	0.60
IRF8	activates	gene	0.60
MAF	activates	gene	0.60
MAPK	activates	gene	0.60
LDL	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TLR	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
EXOSOMES	regulates	gene	0.60
PHAGOCYTOSIS	regulates	gene	0.60
IBA1	activates	gene	0.60
NDUFAF1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELL in their description or question text

No additional research found