Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RFWD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | RFWD3 |
| Key Genes/Proteins | AND, ATM, ATR, DNA, MCM8, RAD51 |
| Related Pathways | ubiquitin-proteasome |
graph TD
RFWD3["RFWD3"]
RFWD3 -->|"catalyzes"| RPA["RPA"]
RFWD3 -->|"catalyzes"| RAD51["RAD51"]
RFWD3 -->|"activates"| MCM8["MCM8"]
RFWD3 -->|"activates"| AND["AND"]
RFWD3 -->|"activates"| VCP["VCP"]
RFWD3 -->|"activates"| ATR["ATR"]
RFWD3 -->|"activates"| RAD54["RAD54"]
ATR -->|"phosphorylates"| RFWD3
ATM["ATM"] -->|"phosphorylates"| RFWD3
DNA["DNA"] -->|"activates"| RFWD3
RAD54 -->|"activates"| RFWD3
RAD51 -->|"activates"| RFWD3
VCP -->|"activates"| RFWD3
MCM8 -->|"activates"| RFWD3| Target | Relation | Type | Str |
|---|---|---|---|
| RPA | catalyzes | protein | 0.90 |
| RAD51 | catalyzes | protein | 0.90 |
| RPA | ubiquitinates | protein | 0.90 |
| RAD51 | ubiquitinates | protein | 0.90 |
| ATM | activates | gene | 0.60 |
| Ubiquitin | activates | protein | 0.60 |
| RAD54 | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| RAD51 | activates | gene | 0.60 |
| MCM8 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| ATR | activates | gene | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RFWD3 in their description or question text
No additional research found