gene

FANCA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FANCA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

22Outgoing

11Incoming

0Experiments

0Debates

Summary

FANCA (Fanconi Anemia Group A): DNA repair gene implicated in neurodegeneration, Parkinson's disease, and genomic stability

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🧬 Gene Info

Gene Symbol	FANCA
Full Name	Fanconi Anemia Group A
Chromosome	16q24.3
Molecular Weight	180 kDa
Amino Acids	1635 aa
Exons	43
UniProt ID	[O15360](https://www.uniprot.org/uniprot/O15360)
Ensembl ID	ENSG00000188191
OMIM	607139
GeneCards	FANCA
Human Protein Atlas	FANCA
Bone marrow	Highest expression, consistent with the essential role in hematopoiesis
Testis	High expression, reflecting ongoing spermatogenesis
Associated Diseases	Fanconi Anemia
Interactions	ATM, ATR, DNA, FANCC, FANCD2, FANCE
KG Connections	33 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FANCA Gene

gene · 2115 words

→

FANCA Protein

protein · 2116 words

→

Pathway Diagram

graph TD
    FANCA["FANCA"]
    Als{"Als"}
    FANCA -->|"interacts with"| Als
    Cancer{"Cancer"}
    FANCA -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    FANCA -->|"interacts with"| Tumor
    TUFM["TUFM"]
    FANCA -->|"interacts with"| TUFM
    Mitochondrial_Function(["Mitochondrial Function"])
    FANCA -->|"interacts with"| Mitochondrial_Function
    neurodegeneration["neurodegeneration"]
    FANCA -->|"implicated in"| neurodegeneration
    FANCD2["FANCD2"]
    FANCD2 -->|"interacts with"| FANCA
    style FANCA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

Target	Relation	Type	Str
Fanconi Anemia	causes	disease	0.90
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	contributes_to	disease	0.65
Senescence	contributes_to	disease	0.65
FANCI	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PPM1D	interacts_with	gene	0.60
Inflammasome	contributes_to	pathway	0.60
Er Stress	contributes_to	pathway	0.60
Apoptosis	contributes_to	pathway	0.60
DNA	interacts_with	gene	0.60
Neuron	contributes_to	cell_type	0.60
CGAS-STING	contributes_to	gene	0.60
Mitochondrial Function	interacts_with	pathway	0.60
Dna Repair	interacts_with	pathway	0.60
Cgas-Sting	contributes_to	pathway	0.60
TUFM	interacts_with	gene	0.60
FANCE	interacts_with	gene	0.60
AIM2	contributes_to	gene	0.60
ATR	interacts_with	gene	0.60

Incoming (11)

Source	Relation	Type	Str
FANCI	interacts_with	gene	0.60
PPM1D	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
FANCD2	interacts_with	gene	0.60
FANCC	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
ATR	interacts_with	gene	0.60
AIM2	contributes_to	gene	0.60
FANCE	interacts_with	gene	0.60
APOPTOSIS	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FANCA in their description or question text

No additional research found