gene

FANCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

13Outgoing

11Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	FANCE
Chromosome	6p21.31
Protein Type	Adaptor Protein
Function	encodes an essential adaptor protein that plays a critical role in the Fanconi anemia (FA) DNA repair pathway.
Molecular Weight	44 kDa
Amino Acids	396 aa
Ensembl ID	ENSG00000112039
GeneCards	FANCE
Human Protein Atlas	FANCE
Human-Mouse	85% identical at the amino acid level
Human-Zebrafish	72% identical
Drosophila	Partial ortholog with 45% identity
Yeast	No clear ortholog (FA pathway is metazoan-specific)
FANCD1 (BRCA2)	Required for homologous recombination
Associated Diseases	neurodegeneration
Interactions	ATM, ATR, DNA, FANCA, FANCC, FANCI
KG Connections	24 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

fance

gene · 2416 words

→

FANCE Protein

protein · 621 words

→

Pathway Diagram

graph TD
    FANCE["FANCE"]
    Als{"Als"}
    FANCE -->|"contributes_to"| Als
    Senescence{"Senescence"}
    FANCE -->|"contributes_to"| Senescence
    AIM2(["AIM2"])
    FANCE -->|"contributes_to"| AIM2
    ATR(["ATR"])
    FANCE -->|"interacts_with"| ATR
    Inflammasome["Inflammasome"]
    FANCE -->|"contributes_to"| Inflammasome
    Er_Stress["Er Stress"]
    FANCE -->|"contributes_to"| Er_Stress
    FANCC(["FANCC"])
    FANCC -->|"interacts_with"| FANCE
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"contributes_to"| FANCE
    ATM(["ATM"])
    ATM -->|"interacts_with"| FANCE
    FANCA(["FANCA"])
    FANCA -->|"interacts_with"| FANCE
    style FANCE fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (13)

Target	Relation	Type	Str
Als	contributes_to	disease	0.65
Senescence	contributes_to	disease	0.65
AIM2	contributes_to	gene	0.60
ATR	interacts_with	gene	0.60
FANCA	interacts_with	gene	0.60
CGAS-STING	contributes_to	gene	0.60
Dna Repair	interacts_with	pathway	0.60
Cgas-Sting	contributes_to	pathway	0.60
P53	interacts_with	protein	0.60
Inflammasome	contributes_to	pathway	0.60
Er Stress	contributes_to	pathway	0.60
Apoptosis	contributes_to	pathway	0.60
Neuron	contributes_to	cell_type	0.60

Incoming (11)

Source	Relation	Type	Str
FANCC	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
FANCA	interacts_with	gene	0.60
ATR	interacts_with	gene	0.60
AIM2	contributes_to	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
DNA	interacts_with	gene	0.60
CGAS-STING	contributes_to	gene	0.60
FANCI	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PPM1D	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FANCE in their description or question text

No additional research found