gene

FANCC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FANCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

19Outgoing

7Incoming

0Experiments

0Debates

Summary

FANCC encodes a core component of the Fanconi anemia DNA repair pathway, with emerging roles in neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	FANCC
Full Name	Fanconi Anemia Group C Protein
Chromosome	9q22.33
Protein Family	Fanconi anemia complementation group
Function	is a core component of the Fanconi anemia (FA) DNA repair pathway, a crucial mechanism for maintaining genomic stability through the repair of DNA interstrand crosslinks (ICLs) [1][2].
Primary Expression	Ubiquitous, high in bone marrow
Molecular Weight	64 kDa
Amino Acids	558 aa
Pathways	pathway: [@pathway]
UniProt ID	Q00597
NCBI Gene ID	2176
Ensembl ID	ENSG00000144567
OMIM	603234
GeneCards	FANCC
Human Protein Atlas	FANCC
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ATM, ATR, DNA, FANCA, FANCE, FANCI
KG Connections	26 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FANCC — AlphaFold Q00597 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FANCC Gene

gene · 2477 words

→

FANCC Protein

protein · 602 words

→

Pathway Diagram

graph TD
    FANCC["FANCC"]
    Als{"Als"}
    FANCC -->|"contributes_to"| Als
    Senescence{"Senescence"}
    FANCC -->|"contributes_to"| Senescence
    APOPTOSIS(["APOPTOSIS"])
    FANCC -->|"contributes_to"| APOPTOSIS
    ATM(["ATM"])
    FANCC -->|"interacts_with"| ATM
    FANCA(["FANCA"])
    FANCC -->|"interacts_with"| FANCA
    DNA(["DNA"])
    FANCC -->|"interacts_with"| DNA
    FANCI(["FANCI"])
    FANCI -->|"interacts_with"| FANCC
    ATR(["ATR"])
    ATR -->|"interacts_with"| FANCC
    PPM1D(["PPM1D"])
    PPM1D -->|"interacts_with"| FANCC
    AIM2(["AIM2"])
    AIM2 -->|"contributes_to"| FANCC
    style FANCC fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (19)

Target	Relation	Type	Str
Als	contributes_to	disease	0.65
Senescence	contributes_to	disease	0.65
CGAS-STING	contributes_to	gene	0.60
FANCI	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PPM1D	interacts_with	gene	0.60
Inflammasome	contributes_to	pathway	0.60
Er Stress	contributes_to	pathway	0.60
Apoptosis	contributes_to	pathway	0.60
APOPTOSIS	contributes_to	gene	0.60
Neuron	contributes_to	cell_type	0.60
DNA	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
FANCA	interacts_with	gene	0.60
FANCE	interacts_with	gene	0.60
AIM2	contributes_to	gene	0.60
ATR	interacts_with	gene	0.60
Dna Repair	interacts_with	pathway	0.60
Cgas-Sting	contributes_to	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
ATR	interacts_with	gene	0.60
AIM2	contributes_to	gene	0.60
ATM	interacts_with	gene	0.60
FANCI	interacts_with	gene	0.60
PPM1D	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FANCC in their description or question text

No additional research found