| Gene Symbol | MATR3 |
| Aliases | MATR3PROTEIN |
| Function | Matr3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | Signals (NLS)**: Two NLS sequences for nuclear import - **C-terminal domain**: M |
| Molecular Weight | 125 kDa |
| Amino Acids | 847 aa |
| Pathways | Autophagy, Proteasome, Dna Repair, autophagy pathway |
| GeneCards | MATR3 |
| Human Protein Atlas | MATR3 |
| N-terminal domain | Contains multiple RG-rich (RGG) repeats involved in RNA binding and phase separation |
| RNA Recognition Motifs (RRMs) | Two RRMs (RRM1 and RRM2) for RNA and DNA binding |
| Nuclear Localization Signals (NLS) | Two NLS sequences for nuclear import |
| C-terminal domain | Mediates protein-protein interactions and dimerization |
| Phosphorylation | Casein kinase 2 (CK2) phosphorylation modulates its RNA binding |
| Sumoylation | SUMO conjugation affects nuclear distribution |
| Associated Diseases | Als, Amyotrophic Lateral Sclerosis, Dementia, frontotemporal dementia |
| Interactions | ALS, AMYOTROPHIC LATERAL SCLEROSIS, App, AUTOPHAGY, CCNF, CHCHD10 |
| KG Connections | 120 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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