| Gene Symbol | ATR |
| Aliases | ATRPROTEIN |
| Protein Type | Kinase |
| Function | encodes a phosphatidylinositol 3-kinase-like serine/threonine kinase that is a central coordinator of replication stress responses and genome maintenance[@cimprich2008][@flynn2011]. |
| Pathways | mTOR, mtor, mTOR signaling, PI3K |
| GeneCards | ATR |
| Human Protein Atlas | ATR |
| FHA Domain | Forkhead-associated domain for protein-protein interactions |
| BRCT Domains | Breast cancer C-terminal domains for DNA binding |
| PI3K Domain | Kinase catalytic domain for phosphorylation activity |
| ATRIP Binding Domain | Interaction site for ATRIP, the essential ATR partner |
| Associated Diseases | Als, Ataxia, Cancer, Infection, Ms, Senescence |
| Known Drugs/Compounds | rapamycin |
| Interactions | AMPK, AND, APOPTOSIS, ARID1A, ATG5, ATM |
| KG Connections | 208 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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