gene 1,682 words KG: ATR
Contents

ATR Gene

🧬 Gene Info
Gene SymbolATR
Protein TypeKinase
Functionencodes a phosphatidylinositol 3-kinase-like serine/threonine kinase that is a central coordinator of replication stress responses and genome maintenance[@cimprich2008][@flynn2011].
PathwaysmTOR, mtor, mTOR signaling, PI3K
GeneCardsATR
Human Protein AtlasATR
Associated DiseasesAls, Ataxia, Cancer, Infection, Ms, Senescence
Known Drugs/Compoundsrapamycin
InteractionsAMPK, AND, APOPTOSIS, ARID1A, ATG5, ATM
KG Connections208 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (8)

R-Loop Resolution Enhancement Therapy
Score: 0.68
Glial Glycocalyx Remodeling Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.85
PARP1 Inhibition Therapy
Score: 0.74

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Apoptosis in Neurodegeneration
entity · KG edge: contributes_to
APE2 Gene
gene · KG edge: participates_in
ARID1A
gene · KG edge: inhibits
ATM Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RAD54 activates ATR
VCP activates ATR
RAD51 activates ATR
ATR associated_with ATM
ATR activates RAD51
FNDC5 activates ATR
ATR activates BAX
ATR activates RAD54
ATR activates VCP
ATR activates FNDC5

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)