| Gene Symbol | HEATR1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | neurons of the brain and spinal cord, where it supports ribosomal RNA processing and protein synthesis essential for neuronal sur |
| Subcellular Localization | the nucleolus, the site of ribosome biogenesis. Its HEAT repeat domains mediate protein-protein interactions essential f |
| Molecular Weight | 299 kDa |
| Pathways | Apoptosis, Cell Cycle, Proteasome, apoptosis pathway, ubiquitin-proteasome |
| Ensembl ID | ENSG00000109118 |
| GeneCards | HEATR1 |
| Human Protein Atlas | HEATR1 |
| Ribosomal Large Subunit Biogenesis | HEATR1 is essential for 60S ribosomal subunit maturation and export from the nucleus to the cytoplasm[@kress2013] |
| rRNA Processing | Required for proper processing of 18S rRNA precursor, the critical step in small ribosomal subunit formation[@tumialis2014] |
| Pre-rRNA Assembly | Associates with the 90S pre-ribosomal particle and participates in early processing steps |
| RNA Polymerase I Transcription | Facilitates transcription of ribosomal DNA by RNA polymerase I in the nucleolus |
| Cell Cycle Regulation | Necessary for cell cycle progression through its role in ribosome production |
| Brain | Cerebral cortex, hippocampus, basal ganglia, and cerebellum |
| Associated Diseases | Tumor |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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