| Gene Symbol | MARCH5 |
| Aliases | MARCH5PROTEIN |
| Protein Type | Ligase |
| Function | encodes a mitochondrial outer membrane E3 ubiquitin ligase that plays critical roles in mitochondrial quality control, dynamics, and innate immune signaling. |
| Subcellular Localization | </td><td>Outer mitochondrial membrane</td></tr> |
| Molecular Weight | 35.3 kDa |
| Amino Acids | 278 aa |
| Ensembl ID | ENSG00000148627 |
| GeneCards | MARCH5 |
| Human Protein Atlas | MARCH5 |
| E2 partners | UBE2D (UbcH5) family, UBE2E1, UBE2J1 |
| Catalytic mechanism | RING domain positions the E2~Ub thioester for direct transfer to substrate lysines |
| Critical residues | His43 and Cys65 are essential for catalytic activity; H43W mutation abolishes ubiquitin ligase function |
| [DRP1](/proteins/drp1-protein) | K48-linked ubiquitination regulates DRP1 activity and turnover at fission sites |
| MFN1/MFN2 | Ubiquitination modulates fusogenic activity |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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