| Gene Symbol | MARCH7 |
| Full Name | Membrane Associated Ring-CH Type Finger 7 |
| Aliases | MARCH7 Protein |
| Protein Type | Ligase |
| Function | is an E3 ubiquitin ligase belonging to the MARCH family of membrane-associated RING-CH proteins. |
| Primary Expression | immune cells and lymphoid tissues, where it regulates various aspects of immune function [@wang2015] |
| Molecular Weight | 75.3 kDa |
| Pathways | Apoptosis, Immune Response, Inflammasome, Innate Immunity, Mapk |
| Ensembl ID | ENSG00000136240 |
| GeneCards | MARCH7 |
| Human Protein Atlas | MARCH7 |
| Ubiquitin Cascade | MARCH7 transfers ubiquitin from an E2 conjugating enzyme to lysine residues on target proteins |
| Chain Types | Catalyzes formation of different ubiquitin chain types (K48, K63) depending on cellular context |
| Substrate Recognition | Recognizes specific substrates through protein-protein interaction motifs |
| Associated Diseases | Ms, Tumor |
| Interactions | AIM2, APOPTOSIS, ASC, ATG5, CASP1, CBL |
| KG Connections | 84 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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