concept

AND

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AND: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11661Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	AND
Key Genes/Proteins	3R-TAU, 4R-TAU, 5-HT1AR, 6-OHDA, A2M, AADC

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Interactions["Interactions"]
        AND["AND"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
        AND["AND"] -->|"participates in"| apoptosis_pathway["apoptosis pathway"]
        AND["AND"] -->|"interacts with"| Alzheimer_s_disease["Alzheimer's disease"]
        AND["AND"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
        TP53["TP53"] -->|"interacts with"| AND["AND"]
        APOPTOSIS_2["APOPTOSIS"] -->|"interacts with"| AND["AND"]
    end
    subgraph Therapeutic["Therapeutic"]
        AND["AND"] -->|"expressed in"| endothelial_cells["endothelial cells"]
    end
    subgraph Pathology["Pathology"]
        AND["AND"] -->|"associated with"| Alzheimer_s_disease_1["Alzheimer's disease"]
        AND["AND"] -->|"associated with"| neurodegeneration["neurodegeneration"]
        AND["AND"] -->|"associated with"| PS1["PS1"]
        AND["AND"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
        MYC["MYC"] -->|"associated with"| AND["AND"]
        JUN["JUN"] -->|"associated with"| AND["AND"]
        APOPTOSIS["APOPTOSIS"] -->|"associated with"| AND["AND"]
    end
    subgraph Signaling["Signaling"]
        CYTOKINES["CYTOKINES"] -->|"activates"| AND["AND"]
    end
    style AND fill:#90a4ae,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style oxidative_stress_response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style apoptosis_pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style endothelial_cells fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_s_disease fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_s_disease_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ubiquitin_proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TP53 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MYC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style CYTOKINES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (6190)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AND	data_in	dataset_row	0.00
genes-and	has_wiki	wiki_page	1.00
wp-3a5eaa1ed68d	has_wiki	wiki_page	1.00
oxidative stress response	participates_in	pathway	0.90
apoptosis pathway	participates_in	pathway	0.80
endothelial cells	expressed_in	cell_type	0.80
neurodegeneration	associated_with	disease	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
PS1	associated_with	gene	0.70
Alzheimer's disease	interacts_with	disease	0.70
Obesity	interacts_with	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Depression	interacts_with	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Dementia	biomarker_for	disease	0.65
Covid	therapeutic_target	disease	0.65
Ischemia	inhibits	disease	0.65
Leukemia	inhibits	disease	0.65
Glaucoma	biomarker_for	disease	0.65
Epilepsy	inhibits	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
Autoimmune	contributes_to	disease	0.65
Autoimmune	expressed_in	disease	0.65
Hypertension	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Obesity	expressed_in	disease	0.65
Stroke	inhibits	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Melanoma	inhibits	disease	0.65
Senescence	therapeutic_target	disease	0.65
Neuropathy	associated_with	disease	0.65
Schizophrenia	regulates	disease	0.65
Depression	regulates	disease	0.65
Retinal Degeneration	activates	disease	0.65
Nociception	regulates	disease	0.65
Parkinson	contributes_to	disease	0.65
Metabolic Syndrome	contributes_to	disease	0.65
Dementia	associated_with	disease	0.65
Huntington	activates	disease	0.65
Stroke	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Aging	expressed_in	disease	0.65
Longevity	activates	disease	0.65
Ataxia	expressed_in	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Melanoma	activates	disease	0.65
Cardiac	protects_against	disease	0.65

Incoming (5471)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AND	data_in	dataset_row	0.00
wp-3a5eaa1ed68d	described_by	wiki_page	1.00
genes-and	described_by	wiki_page	1.00
h-0758b337	targets	hypothesis	0.80
h-7d4a24d3	targets	hypothesis	0.80
h-db6aa4b1	targets	hypothesis	0.80
NEURON	associated_with	gene	0.60
MDM2	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
P53	associated_with	gene	0.60
NOTCH1	associated_with	gene	0.60
MYC	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
C-JUN	activates	gene	0.60
JUN	activates	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
CANCER	contributes_to	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
P53	contributes_to	gene	0.60
TP53	therapeutic_target	gene	0.60
CANCER	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
DNA	associated_with	gene	0.60
JUN	therapeutic_target	gene	0.60
LDHA	activates	gene	0.60
MYC	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AURKB	regulates	gene	0.60
DNA	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
MYC	regulates	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
PI3K	activates	gene	0.60
HIF-1Α	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
ROS	activates	gene	0.60
AKT	expressed_in	gene	0.60
TNF	therapeutic_target	gene	0.60
CANCER	associated_with	gene	0.60
MTOR	activates	gene	0.60
PI3K	expressed_in	gene	0.60
AKT1	therapeutic_target	gene	0.60
GENES	contributes_to	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
IL-6	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
POLE	associated_with	gene	0.60
CASP3	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

AND