gene 1,373 words KG: ent-gene-eb1528a1
Contents

AKT1 Gene

🧬 Gene Info
Gene SymbolAKT1
Full NameAKT Serine/Threonine Kinase 1
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Amino Acids480 aa
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mapk
Ensembl IDENSG00000142208
GeneCardsAKT1
Human Protein AtlasAKT1
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAndrographis paniculata, Atbc, berberine, Coumestrol, COUMESTROL, DEP
InteractionsACTB, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
KG Connections1550 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
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Related Analyses (11)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: interacts_with
AKT2 Gene
gene · KG edge: associated_with
AKT3 Gene
gene · KG edge: associated_with
ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3
gene · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-eb1528a1 data_in benchmark_ot_ad_answer_key:AKT1
benchmark_ot_ad_answer_key:AKT1 data_in ent-gene-eb1528a1

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