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protein 1,462 words KG: AKT1
Contents

AKT1 Protein (Protein Kinase B Alpha)

🔬 Protein Info
Gene SymbolAKT1
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Amino Acids480 aa
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mapk
Ensembl IDENSG00000142208
GeneCardsAKT1
Human Protein AtlasAKT1
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAndrographis paniculata, Atbc, berberine, Coumestrol, COUMESTROL, DEP
InteractionsACTB, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
KG Connections1557 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (30)

APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88

Related Analyses (13)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (9)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_targetACTB Gene
gene · KG edge: interacts_withAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_withnct05508789
clinical_trial · Pages share 3 hypothesesBEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 3 hypotheses

Knowledge Graph (12 edges)

COUMESTROL interacts_with AKT1
OPTN interacts_with AKT1
CASP3 regulates AKT1
AKT1 regulates CALCOCO2
AKT1 regulates CGAS
AKT1 regulates CFTR
AKT1 interacts_with SQSTM1
AKT1 interacts_with RPS6KB1
AKT1 interacts_with GRB2
AKT1 interacts_with RHEB

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