Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GAP26: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GAP26 |
Knowledge base pages for this entity
graph TD
GAP26[GAP26]
GAP26 -->|inhibits| GJA1[GJA1]
GAP26 -->|inhibits| Astrogliosis[Astrogliosis]
GAP26 -->|treats| Ischemic_Brain_Injury[Ischemic Brain Injury]
GAP26 -->|treats| ischemic_brain_injury[ischemic brain injury]
GAP26 -->|inhibits| CONNEXIN43[CONNEXIN43]
GAP26 -->|suppresses| glutamate_release[glutamate release]
GAP26 -->|upregulates| AKT[AKT]
GAP26 -->|inhibits| astrogliosis[astrogliosis]
GAP26 -->|downregulates| CASP3[CASP3]| Target | Relation | Type | Str |
|---|---|---|---|
| Functional Recovery | associated_with | phenotype | 0.90 |
| GJA1 | inhibits | protein | 0.90 |
| Cerebral Infarct Volume | associated_with | biomarker | 0.90 |
| cerebral infarct volume | associated_with | phenotype | 0.88 |
| Ischemic Brain Injury | treats | disease | 0.85 |
| ischemic brain injury | treats | disease | 0.85 |
| CONNEXIN43 | inhibits | protein | 0.85 |
| Astrogliosis | inhibits | process | 0.85 |
| GJA1 | interacts_with | protein | 0.85 |
| Astrogliosis | associated_with | process | 0.85 |
| glutamate release | suppresses | process | 0.82 |
| motor coordination | associated_with | phenotype | 0.82 |
| CASP3 | downregulates | protein | 0.80 |
| astrogliosis | inhibits | process | 0.80 |
| AKT | upregulates | protein | 0.80 |
| spatial memory | associated_with | phenotype | 0.80 |
| AKT1 | upregulates | protein | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GAP26 in their description or question text
No additional research found