| Gene Symbol | ADAM17 |
| Aliases | ADAM17PROTEIN |
| Chromosome | 2p25.1 |
| Function | is a transmembrane zinc-dependent metalloproteinase that functions as the primary alpha-secretase for amyloid precursor protein (APP) processing. |
| Exons | 22 |
| Pathways | Notch, Apoptosis, Stem Cell, Phagocytosis, Amyloid |
| GeneCards | ADAM17 |
| Human Protein Atlas | ADAM17 |
| Signal Peptide | Directs protein to the secretory pathway |
| Prodomain | N-terminal propeptide that maintains zymogen inactivity (approximately 20 kDa) |
| Associated Diseases | Cancer, Neurodegeneration |
| Interactions | Actin, AD, ADAM10, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID |
| KG Connections | 178 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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