gene 2,000 words KG: ADAM17
Contents

ADAM17 Gene

🧬 Gene Info
Gene SymbolADAM17
Chromosome2p25.1
Functionis a transmembrane zinc-dependent metalloproteinase that functions as the primary alpha-secretase for amyloid precursor protein (APP) processing.
Exons22
PathwaysNotch, Apoptosis, Stem Cell, Phagocytosis, Amyloid
GeneCardsADAM17
Human Protein AtlasADAM17
Associated DiseasesCancer, Neurodegeneration
InteractionsActin, AD, ADAM10, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID
KG Connections176 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (8)

TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (2)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (9)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
APH1A Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

ADAM17 activates TNF-alpha
ADAM17 activates EGFR ligands
ADAM17 regulates epithelial tissue development
ADAM17 regulates p75NTR
ADAM17 regulates tPA
ADAM17 regulates fibrin
ADAM17 regulates nerve_conduction_velocity
PDK1 regulates ADAM17
RSK2 regulates ADAM17
iRhom2 regulates ADAM17

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