gene

P16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

426Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	P16
Primary Expression	Ca1, Thalamus, Hypothalamus
Pathways	Cell Cycle, Dna Methylation, Angiogenesis, Histone Modification, Epigenetic
GeneCards	P16
Human Protein Atlas	P16
Associated Diseases	Aging, ALS, Alzheimer, Cancer, Epilepsy, glioblastoma
Interactions	ACETYL-COA, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	425 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

CEP164 — Centrosomal Protein 164

gene · 1460 words

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Pathway Diagram

graph TD
    P16["P16"]
    Senescence{"Senescence"}
    P16 -->|"activates"| Senescence
    Aging{"Aging"}
    P16 -->|"activates"| Aging
    Als{"Als"}
    P16 -->|"therapeutic_target"| Als
    Cancer{"Cancer"}
    P16 -->|"therapeutic_target"| Cancer
    AGING(["AGING"])
    AGING -->|"activates"| P16
    ERK(["ERK"])
    ERK -->|"activates"| P16
    CDKN2A(["CDKN2A"])
    CDKN2A -.->|"inhibits"| P16
    GENES(["GENES"])
    GENES -.->|"inhibits"| P16
    style P16 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#e0e0e0

Outgoing (268)

Target	Relation	Type	Str
Senescence	activates	disease	0.95
Aging	activates	disease	0.85
High-Grade Serous Ovarian Cancer	biomarker_for	disease	0.85
Als	therapeutic_target	disease	0.85
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Senescence	inhibits	disease	0.75
Senescence	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
DNA	therapeutic_target	gene	0.70
AKT	activates	gene	0.70
P21	regulates	gene	0.70
RB1	regulates	protein	0.70
Cell Cycle	activates	pathway	0.70
glioblastoma	associated_with	disease	0.70
Cancer	regulates	disease	0.65
Aging	regulates	disease	0.65
Als	expressed_in	disease	0.65
Senescence	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Infection	therapeutic_target	disease	0.65
Pancreatic Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Parkinson	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Longevity	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Senescence	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Breast Cancer	contributes_to	disease	0.65
ALS	activates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	treats	disease	0.65
Carcinoma	treats	disease	0.65
Als	inhibits	disease	0.65
Pulmonary Fibrosis	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Pancreatic Cancer	treats	disease	0.65
Senescence	biomarker_for	disease	0.65
Parkinson	activates	disease	0.65
Aging	treats	disease	0.65
Als	treats	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65

Incoming (158)

Source	Relation	Type	Str
P53	activates	gene	0.70
GENES	inhibits	gene	0.70
ERK	activates	gene	0.70
CDKN2A	inhibits	gene	0.70
AGING	activates	gene	0.70
SMAD4	inhibits	gene	0.60
CANCER	treats	gene	0.60
STAT3	inhibits	gene	0.60
IL6	inhibits	gene	0.60
P53	biomarker_for	gene	0.60
IL-6	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ATM	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
BNIP3	activates	gene	0.60
DNA	activates	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
AGING	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
SOX10	associated_with	gene	0.60
NF1	associated_with	gene	0.60
CDKN2A	expressed_in	gene	0.60
BLM	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
IL-1	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
MMP1	associated_with	gene	0.60
WNT	activates	gene	0.60
CXCL8	activates	gene	0.60
GSK3	activates	gene	0.60
CYTOKINES	activates	gene	0.60
KRAS	inhibits	gene	0.60
TP53	inhibits	gene	0.60
PTEN	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
AGING	regulates	gene	0.60
CANCER	regulates	gene	0.60
MET	activates	gene	0.60
ONCOGENES	activates	gene	0.60
MAPK	activates	gene	0.60
EGFR	activates	gene	0.60
IL-6	regulates	gene	0.60
RNA	inhibits	gene	0.60
WT1	biomarker_for	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p16^INK4a-CCF Axis as Senolytic Timing Biomarker	0.755	molecular biology	What is the optimal therapeutic window t
Dasatinib plus Quercetin Senolytic Clearance of p16Ink4a-Hig	0.680	neurodegeneration	-
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.564	neuroinflammation	What molecular mechanisms drive the tran

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
UNC93B1 promotes pancreatic cancer progression through modulation of cGAS-STING [PMID:41716413]	Yang H, Li Y, Su J, Zhang H, Zhu W et al	Front Immunol	2026	0

Debates (1)

Multi-agent debates referencing this entity

The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning P16 in their description or question text

No additional research found