concept

IL-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

319Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IL-4
Key Genes/Proteins	AGING, AHR, ALZHEIMER, AMPK, AMYLOID, Amyloid-Beta
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    IL_4["IL-4"]
    style IL_4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IL_4 -->|"activates"| Microglia_Reactivity["Microglia Reactivity"]
    IL_4 -.->|"prevents"| senescence["senescence"]
    IL_4 -->|"regulates"| ARRB1([ARRB1])
    IL_4 -->|"regulates"| ARRB2([ARRB2])
    IL_4 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL_4 -->|"regulates"| Pain["Pain"]
    IL_4 -->|"regulates"| Tumor["Tumor"]
    IL_4 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    IL_4 -->|"activates"| Inflammation["Inflammation"]
    IL_4 -->|"activates"| Parkinson["Parkinson"]
    TNF([TNF]) -->|"regulates"| IL_4
    NF__B(["NF-KappaB"]) -->|"activates"| IL_4
    IL_6([IL-6]) -->|"activates"| IL_4
    JNK([JNK]) -->|"activates"| IL_4
    P38([P38]) -->|"activates"| IL_4
    PARKINSON([PARKINSON]) -->|"activates"| IL_4
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"activates"| IL_4
    ALZHEIMER([ALZHEIMER]) -->|"target for"| IL_4
    APOPTOSIS([APOPTOSIS]) -->|"target for"| IL_4
    NLRP3([NLRP3]) -->|"target for"| IL_4

Outgoing (189)

Target	Relation	Type	Str
Microglia Reactivity	activates	process	0.95
senescence	prevents	process	0.95
M2 Microglial Polarization	mediates	process	0.85
ARRB1	regulates	gene	0.85
ARRB2	regulates	gene	0.85
Ms	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Senescence	protects_against	disease	0.65
Als	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	activates	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Aging	protects_against	disease	0.65
ALS	activates	disease	0.65
Senescence	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Tumor	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Pain	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	regulates	disease	0.65
Stroke	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Vascular Dementia	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
AMYLOID-BETA	activates	gene	0.60
APP/PS1	activates	gene	0.60
IL-6	activates	gene	0.60
FLAVONOIDS	activates	gene	0.60
Monocyte	expressed_in	cell_type	0.60

Incoming (130)

Source	Relation	Type	Str
PNS-R1	downregulates	compound	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.64
CHI3L1	inhibits	gene	0.60
IRF7	inhibits	gene	0.60
AMPK	activates	gene	0.60
STROKE	activates	gene	0.60
NEAT1	activates	gene	0.60
IL-1	associated_with	gene	0.60
TNC	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
P2RX7	regulates	gene	0.60
NAD	activates	gene	0.60
IL-17	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
FLAVONOIDS	activates	gene	0.60
APP/PS1	activates	gene	0.60
CXCL8	inhibits	gene	0.60
TNF	regulates	gene	0.60
NF-ΚB	activates	gene	0.60
IL-6	activates	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
STAT6	protects_against	gene	0.60
CD8	associated_with	gene	0.60
OCLN	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
DNA	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
JAK	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NLRP3	therapeutic_target	gene	0.60
TNF	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ALS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ASC	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PARKINSON	regulates	gene	0.60
STROKE	therapeutic_target	gene	0.60
IL-1	activates	gene	0.60
EGF	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL-4 in their description or question text

No additional research found