gene

C1QA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1QA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

705Connections

8Hypotheses

14Analyses

50Outgoing

50Incoming

12Experiments

18Debates

Summary

C1QA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with AD, ALI, ALS. Connected to 167 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	C1QA
Full Name	Complement Component 1, Q Subunit A
Chromosome	1p36.33
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	The C1QA gene encodes the A-chain of complement component C1q.
Mechanism of Action	Complement cascade inhibitor or antibody-mediated neutralization
Druggability	Low (0.41)
Clinical Stage	Phase II
Amino Acids	245 aa
Pathways	Complement, Complement system, Synaptic pruning, complement activation
UniProt ID	P02787
NCBI Gene ID	712
Ensembl ID	ENSG00000196954
OMIM	120550
GeneCards	C1QA
Human Protein Atlas	C1QA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ANX005
Interactions	AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	Complement C1q Mimetic Decoy Therapy Complement C1QA Spatial Gradient in Cortical Layer Complement C1q Subtype Switching (+3 more)
KG Connections	704 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — C1QA Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1PK6 — X-ray / Cryo-EM

🔮 AI Predicted Structure

P02787 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

C1QA Gene

gene · 1552 words

→

C1QA Gene — Complement Component 1q A Chain

gene · 2340 words

→

Pathway Diagram

graph TD
    C1QA["C1QA"]
    C1QA -->|"regulates"| complement_activation["complement activation"]
    C1QA -->|"expressed in"| _middle_temporal_gyrus__spiny_["'middle temporal gyrus'_spiny_L3"]
    C1QA -->|"expressed in"| _middle_temporal_gyrus__aspiny["'middle temporal gyrus'_aspiny_L3"]
    C1QA -->|"activates"| Alzheimer["Alzheimer"]
    C1QA -->|"activates"| Dementia["Dementia"]
    C1QA -->|"activates"| Als["Als"]
    C1QA -->|"activates"| Inflammation["Inflammation"]
    C1QA -->|"activates"| Neuroinflammation["Neuroinflammation"]
    C1QA -->|"activates"| Anxiety["Anxiety"]
    h_5a55aabc["h-5a55aabc"] -->|"target for"| C1QA
    h_1fe4ba9b["h-1fe4ba9b"] -->|"target for"| C1QA
    CTSB["CTSB"] -->|"activates"| C1QA
    C1Q["C1Q"] -->|"activates"| C1QA
    SPP1["SPP1"] -->|"activates"| C1QA
    SPI1["SPI1"] -->|"expressed in"| C1QA
    APOE["APOE"] -->|"activates"| C1QA
    MMP9["MMP9"] -.biomarker for.-> C1QA

Outgoing (481)

Target	Relation	Type	Str
Hallmark_Complement	involved_in	pathway	0.90
Complement Cascade	activates	pathway	0.90
ATHEROSCLEROSIS	associated_with	entity	0.90
synapses	associated_with	cell_type	0.85
Atherosclerosis	biomarker_for	disease	0.85
Alzheimer'S Disease	biomarker_for	disease	0.85
Microglial Synaptic Elimination	mediates	process	0.85
Atherosclerosis	associated_with	disease	0.85
Atherosclerotic Plaques	biomarker_for	disease	0.85
synaptic_elimination	causes	biological_process	0.80
A1 astrocyte	inhibits	cell_type	0.80
biomarker_for	biomarker_for	phenotype	0.80
Ischemic Stroke	risk_factor_for	disease	0.78
neurons	expressed_in	cell_type	0.75
Als	activates	disease	0.75
SLC17A7	loss_linked_to	gene	0.75
excitatory neurons	expressed_in	cell_type	0.75
GFAP	astrocyte_response_linked_to	protein	0.75
myelin membranes	binds	cell_type	0.70
synaptic pruning	facilitates	mechanism	0.70
microglial activation	modulates	mechanism	0.70
middle_temporal_gyrus_aspiny_L3	expressed_in	cell_type	0.70
microglial recognition	modulates	mechanism	0.70
middle_temporal_gyrus_spiny_L3	expressed_in	cell_type	0.70
CLEC7A	binds	protein	0.70
CLEC7A	engages	protein	0.70
COMPLEMENT	activates	gene	0.70
SIGLEC3	binds	protein	0.70
Phagocytosis	activates	pathway	0.70
TREM2	associated_with	protein	0.70
Complement	activates	pathway	0.70
SIGLEC3	engages	protein	0.70
synaptic engulfment	causes	mechanism	0.70
macrophages	treats	cell_type	0.70
middle_temporal_gyrus_spiny_L5	expressed_in	cell_type	0.70
microglial receptors	interacts_with	cell_type	0.70
complement cascade	participates_in	pathway	0.70
C1Q	activates	gene	0.70
disease-altered synapses	targets	phenotype	0.70
complement activation	regulates	pathway	0.70
synaptic membranes	binds	cell_type	0.70
TREM2-dependent pruning	activates	mechanism	0.70
Aging	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	associated_with	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Anxiety	activates	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	activates	disease	0.65

Incoming (224)

Source	Relation	Type	Str
h-immunity-c3bc272f	relates_to	hypothesis	0.00
SPP1	upregulates	gene	0.90
h-1fe4ba9b	targets	hypothesis	0.90
h-seaad-5b3cb8ea	targets_gene	hypothesis	0.90
h-a8165b3b	targets	hypothesis	0.90
h-f19b8ac8	targets	hypothesis	0.90
h-5a55aabc	targets	hypothesis	0.90
C4B	pathway_partner	gene	0.90
h-494861d2	targets	hypothesis	0.90
SPI1	regulates	entity	0.85
TREM2	co-expressed_with	gene	0.80
C1Q	co_mentioned_with	gene	0.80
SLC17A7	synapse_loss_linked_to	gene	0.75
APOE	interacts_with	gene	0.70
APOE4	causes	gene	0.70
CYTOKINES	therapeutic_target	gene	0.60
COMPLEMENT	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEUROTOXICITY	activates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
APOE	activates	gene	0.60
C1QB	regulates	gene	0.60
C1R	regulates	gene	0.60
SIRPA	regulates	gene	0.60
C1QC	regulates	gene	0.60
C1S	regulates	gene	0.60
MERTK	regulates	gene	0.60
LRP1	activates	gene	0.60
APP	regulates	gene	0.60
CLU	regulates	gene	0.60
CST3	regulates	gene	0.60
APBB1	regulates	gene	0.60
SYN1	activates	gene	0.60
MBP	activates	gene	0.60
RAC1	activates	gene	0.60
MOG	activates	gene	0.60
C1QB	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
AIF1	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
CYBB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
ITGAM	biomarker_for	gene	0.60
CCR1	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CYBB	associated_with	gene	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
Complement C1q Mimetic Decoy Therapy	0.695	neurodegeneration	Synaptic pruning by microglia in early A
Complement C1QA Spatial Gradient in Cortical Layers	0.678	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Complement C1q Subtype Switching	0.665	neurodegeneration	4R-tau strain-specific spreading pattern
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.659	neurodegeneration	What molecular mechanisms underlie the d

Complement-Mediated Synaptic Pruning Dysregulation	0.612	neurodegeneration	Gene expression changes in aging mouse b
Complement-Mediated Synaptic Protection	0.580	neurodegeneration	Neuroinflammation and microglial priming
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor

Mentioning Analyses (14)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-21 | 1 hypotheses Top: 0.582

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.455

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747

What molecular mechanisms underlie the dose-dependent protective effects of the

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.659

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (12)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	Human atherosclerotic plaque s	proposed	N/A
C1q neutralization experiment	validation	perioperative neurocognitive d	0.900	0.00	rats	proposed	N/A
scRNA-seq analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	0.00	human atherosclerotic plaque s	proposed	N/A
Sevoflurane-induced neurotoxicity (SIN) model in rats	validation	perioperative neurocognitive d	0.900	0.00	rats	proposed	N/A
Machine learning-based identification of C1Q hub genes	exploratory	Atherosclerosis	0.900	0.00	Human bulk RNA sequencing data	proposed	N/A
Gene expression validation in apoE-/- mice	validation	Atherosclerosis	0.850	0.00	apoE-/- mice	proposed	N/A
ox-LDL treatment of RAW264.7 macrophages	exploratory	Atherosclerosis	0.850	0.00	RAW264.7 macrophages	proposed	N/A
Validation of hub genes in ox-LDL treated RAW264.7 macrophages	exploratory	Atherosclerosis	0.800	0.00	RAW264.7 macrophages	proposed	N/A
Validation of hub genes in apoE-/- atherosclerotic mice	validation	Atherosclerosis	0.800	0.00	apoE-/- mice	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Alzheimer's Disease	0.400	0.50	mouse	proposed	$200,000
Experiment: Autoimmune Hypothesis Testing in AD	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
An integrative analysis of single-cell and bulk transcriptome and bidirectional [PMID:38179058]	Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J,	Front Immunol	2023	2
Early complement genes are associated with visual system degeneration in multipl [PMID:31289819]	Fitzgerald KC, Kim K, Smith MD, Aston SA	Brain	2019	1
Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964]	Righes Marafiga J, Vu T, Bowlus J, Barab	Progress in neurobiology	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	Geroscience	2026	0
Robust characterization and interpretation of rare pathogenic cell populations f [PMID:41547856]	Zhang X, Yu Z, Hao G, Yao Q, Hu Y et al.	Nat Commun	2026	0
Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross-Species Transcr [PMID:41664952]	Arif M, Hasan MN, Nozaki N, Ide Y, Akiya	Mol Carcinog	2026	0
Structural signature of plasma proteins classifies the status of Alzheimer's dis [PMID:41760935]	Son A, Kim H, Diedrich JK, Bamberger C,	Nat Aging	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	GeroScience	2026	0
Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: se [PMID:41853292]	Zhai X, Lin X, Zhang L, Ren Y, Miao H, M	Frontiers in immunology	2026	0
Proteomic Signature in Men with Central Serous Chorioretinopathy. [PMID:41641862]	Chambon C, Picard E, Zola M, Aichedo S,	Journal of proteome research	2026	0
Machine Learning and Blood-Targeted Proteomics Enable Early Prediction and Etiol [PMID:41683823]	Starodubtseva N, Tokareva A, Kononikhin	International journal of molec	2026	0
Club cell RhoA activation amplifies allergic airway inflammation by regulating e [PMID:41633491]	Tu W, Wu M, Wan R, Alphonse M, Gu W, Gho	The Journal of allergy and cli	2026	0
Identifying the hub genes in macrophage infiltration and verifying of the role o [PMID:41730938]	Tang L, Xu Y, Nong Z, Li F, Pan L	Scientific reports	2026	0
Sex-Specific Molecular Architecture of Microglia-Mediated Neuronal Pruning Acros [PMID:41324815]	Sanfilippo C, Castrogiovanni P, Imbesi R	Molecular neurobiology	2025	0
Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649]	Griggs M, Daylor V, Petrucci T, Weintrau	ImmunoHorizons	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007]	Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ,	Journal of neuroinflammation	2024	0
Identification of crosstalk genes and immune characteristics between Alzheimer's [PMID:39188714]	An W, Zhou J, Qiu Z, Wang P, Han X, Chen	Frontiers in immunology	2024	0

Debates (18)

Multi-agent debates referencing this entity

While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms

closed · Rounds: 4 · Score: 0.71 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.66 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.64 · 2026-04-21

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-21

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

The study shows homozygous R136S fully rescues APOE4-driven pathology while hete

closed · Rounds: 4 · Score: 0.81 · 2026-04-14

Related Research

Hypotheses and analyses mentioning C1QA in their description or question text

C1QA

Understanding Entity Pages

Summary

Wiki Pages (2)

C1QA Gene

C1QA Gene — Complement Component 1q A Chain

Pathway Diagram

Outgoing (481)

Incoming (224)

Targeting Hypotheses (8)

Mentioning Analyses (14)

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

Are interneuron oscillation deficits compensatory responses or primary pathologi

What molecular mechanisms underlie the dose-dependent protective effects of the

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

What are the specific molecular mechanisms by which C1Q components drive atheros

Neuroinflammation and microglial priming in early Alzheimer's Disease

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Immune atlas neuroinflammation analysis in neurodegeneration

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Synaptic pruning by microglia in early AD

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (12)

Related Papers (20)

Debates (18)

While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

The fundamental premise remains unvalidated despite extensive mechanistic specul

The fundamental premise remains unvalidated despite extensive mechanistic specul

The fundamental premise remains unvalidated despite extensive mechanistic specul

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

The study shows homozygous R136S fully rescues APOE4-driven pathology while hete

Related Research

Complement-Mediated Synaptic Pruning Dysregulation

Complement-Mediated Synaptic Protection

Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuro