gene

CLEC7A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLEC7A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

2Analyses

36Outgoing

16Incoming

0Experiments

3Debates

Summary

CLEC7A is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Parkinson's disease, ischemic stroke. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CLEC7A
Protein Type	Receptor
Function	CLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM.
Pathways	Amyloid, unfolded protein response, lipid metabolism
Ensembl ID	ENSG00000172243
GeneCards	CLEC7A
Human Protein Atlas	CLEC7A
NFAT	gene transcription for immune activation
CARD9/BCL10/MALT1	inflammasome-independent cytokine production
Associated Diseases	ischemic stroke, Parkinson's disease
Interactions	AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE
KG Connections	52 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CLEC7A Gene

gene · 939 words

→

CLEC7A / Dectin-1 Protein

protein · 881 words

→

Pathway Diagram

graph TD
    CLEC7A["CLEC7A"]
    Parkinson_s_disease{"Parkinson's disease"}
    CLEC7A -->|"associated with"| Parkinson_s_disease
    neuroinflammation["neuroinflammation"]
    CLEC7A -->|"regulates"| neuroinflammation
    ischemic_stroke{"ischemic stroke"}
    CLEC7A -->|"associated with"| ischemic_stroke
    synapse_elimination["synapse elimination"]
    CLEC7A -->|"regulates"| synapse_elimination
    Gal3["Gal3"]
    CLEC7A -->|"regulates"| Gal3
    TREM2["TREM2"]
    CLEC7A -->|"regulates"| TREM2
    Syk["Syk"]
    CLEC7A -->|"activates"| Syk
    NOX2["NOX2"]
    CLEC7A -->|"regulates"| NOX2
    phagocytosis["phagocytosis"]
    CLEC7A -->|"regulates"| phagocytosis
    pyroptosis["pyroptosis"]
    CLEC7A -->|"regulates"| pyroptosis
    microglia_activation["microglia activation"]
    CLEC7A -->|"regulates"| microglia_activation
    neurodegeneration["neurodegeneration"]
    CLEC7A -->|"implicated in"| neurodegeneration
    style CLEC7A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

Target	Relation	Type	Str
Parkinson's disease	associated_with	disease	0.90
ischemic stroke	associated_with	disease	0.90
synapse elimination	regulates	biological_process	0.90
NOX2	regulates	protein	0.80
Gal3	regulates	protein	0.80
TREM2	regulates	gene	0.80
Syk	activates	protein	0.80
microglia activation	regulates	biological_process	0.80
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Amyloid	activates	pathway	0.60
ALZHEIMER	activates	gene	0.60
RNA	activates	gene	0.60
MICROGLIA	activates	gene	0.60
MIR-155	activates	gene	0.60
Microglia	activates	cell_type	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
TREM2	activates	gene	0.60
EGR3	activates	gene	0.60
unfolded protein response	participates_in	pathway	0.55
DAM microglia	expressed_in	cell_type	0.55
lipid metabolism	participates_in	pathway	0.55
CTSB	activates	gene	0.55
CTSD	activates	gene	0.55
CTSL	activates	gene	0.55
GPNMB	activates	gene	0.55
LGALS3	activates	gene	0.55
LPL	activates	gene	0.55
SPP1	activates	gene	0.55
TYROBP	activates	gene	0.55
LIPA	activates	gene	0.55
Microglia	expressed_in	cell_type	0.55
ALZHEIMER'S	activates	concept	0.50

Incoming (16)

Source	Relation	Type	Str
C1QA	engages	protein	0.70
C1QA	binds	protein	0.70
TREM2	co-expressed in	gene	0.70
APOE	activates	gene	0.60
AKT3	activates	gene	0.60
CASP1	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MIR-155	activates	gene	0.60
MICROGLIA	activates	gene	0.60
RNA	activates	gene	0.60
AMYLOID	activates	gene	0.60
AXL	activates	gene	0.55
CD9	activates	gene	0.55
microglia	activates	cell_type	0.50
GALECTIN-3	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-21 | 1 hypotheses Top: 0.582

Spatial Transcriptomics Analysis of Alzheimer's Disease Brain Regions

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CLEC7A in their description or question text

No additional research found