concept

SYNAPTIC PRUNING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC PRUNING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

313Connections

6Hypotheses

3Analyses

50Outgoing

50Incoming

11Experiments

3Debates

Summary

SYNAPTIC PRUNING is a concept in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with ALS, Aging, Als. Connected to 140 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SYNAPTIC PRUNING
Key Genes/Proteins	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    SYNAPTIC_PRUNING["SYNAPTIC PRUNING"]
    SYNAPTIC_PRUNING -->|"activates"| neurodegeneration["neurodegeneration"]
    SYNAPTIC_PRUNING -->|"activates"| Alzheimer["Alzheimer"]
    SYNAPTIC_PRUNING -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYNAPTIC_PRUNING -->|"activates"| Als["Als"]
    SYNAPTIC_PRUNING -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SYNAPTIC_PRUNING -->|"activates"| Ms["Ms"]
    SYNAPTIC_PRUNING -->|"regulates"| Autism["Autism"]
    SYNAPTIC_PRUNING -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    complement_activation["complement activation"] -->|"activates"| SYNAPTIC_PRUNING
    microglia["microglia"] -->|"activates"| SYNAPTIC_PRUNING
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| SYNAPTIC_PRUNING
    MICROGLIA["MICROGLIA"] -->|"activates"| SYNAPTIC_PRUNING
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| SYNAPTIC_PRUNING
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| SYNAPTIC_PRUNING
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| SYNAPTIC_PRUNING
    P62["P62"] -->|"activates"| SYNAPTIC_PRUNING
    COMPLEMENT["COMPLEMENT"] -->|"inhibits"| SYNAPTIC_PRUNING

Outgoing (190)

Target	Relation	Type	Str
Dysfunctional Synapses	targets	phenotype	0.90
Synaptic Plasticity	regulates	process	0.90
Weakened Synapses	targets	phenotype	0.90
Learning And Memory	regulates	process	0.90
MICROGLIA	activates	gene	0.90
Aged Brain	expressed_in	brain_region	0.85
Neuronal Activity	regulates	process	0.85
Synapse Formation	associated_with	process	0.85
Memory Strength	modulates	phenotype	0.80
Cognitive Decline	correlates_with	phenotype	0.80
Als	associated_with	disease	0.75
Inflammation	regulates	disease	0.75
neurodegeneration	activates	process	0.75
Neurodegeneration	activates	disease	0.75
Regulated Cell Death	associated_with	process	0.70
MICROGLIA	regulates	gene	0.70
OVERVIEW	regulates	gene	0.70
NEURON	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
COMPLEMENT	implicated_in	gene	0.70
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.70
NEURON	implicated_in	gene	0.70
PHAGOCYTOSIS	activates	gene	0.70
Phagocytosis	activates	pathway	0.70
Complement	associated_with	pathway	0.70
Neuroinflammation	regulates	disease	0.65
Aging	activates	disease	0.65
Aging	associated_with	disease	0.65
Autism	regulates	disease	0.65
Anxiety	activates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
Depression	regulates	disease	0.65
Depression	activates	disease	0.65
Aging	regulates	disease	0.65
Autoimmune	activates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Stroke	implicated_in	disease	0.65
Infection	implicated_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
Epilepsy	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Multiple Sclerosis	implicated_in	disease	0.65
Parkinson	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	interacts_with	disease	0.65

Incoming (123)

Source	Relation	Type	Str
MICROGLIA	mediates	cell_type	0.95
Autophagy	involved_in	process	0.95
Microglia	mediates	cell_type	0.95
Complement	mediates	pathway	0.95
Complement System	mediates	pathway	0.90
MICROGLIA	associated_with	gene	0.90
C1Q	mediates	protein	0.85
Complement Inhibition	inhibits	mechanism	0.85
C3	involved_in	protein	0.85
CR3	involved_in	receptor	0.85
C1q	involved_in	protein	0.85
CR3	mediates	receptor	0.85
C1Q	involved_in	protein	0.85
C1q-C3-CR3 Pathway	mediates	pathway	0.85
C1Q	enhances	gene	0.80
TREM2	enhances	gene	0.80
C1q	mediates	protein	0.80
NEURODEGENERATION	activates	gene	0.70
Osteopontin	regulates	protein	0.70
complement activation	activates	process	0.70
C1QA	facilitates	protein	0.70
trained microglia	hyperactive	cell_type	0.70
microglia	activates	cell_type	0.70
TREM2	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
MITOPHAGY	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
TSC2	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
SYNAPSE	interacts_with	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
APP	activates	gene	0.60
GUT-BRAIN AXIS	regulates	gene	0.60
neurons	activates	cell_type	0.60
synaptic plasticity	mediates	pathway	0.60
COMPLEMENT	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
C1Q	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
GENES	regulates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.663	cell biology	What is the relative contribution of con
Complement-Mediated Synaptic Pruning Dysregulation	0.612	neurodegeneration	Gene expression changes in aging mouse b
Synaptic Pruning Precision Therapy	0.612	Alzheimer's disease	Neuroinflammation and microglial priming
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec

Microglial TREM2 Activation to Enhance Synaptic Pruning Regu	0.510	connectomics	Human connectome alterations in Alzheime

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Network pharmacology analysis of QTJD active compounds and pathways	exploratory	Mycoplasma pneumoniae pneumoni	0.900	computational network analysis	proposed	N/A
C1q neutralization experiment	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
scRNA-seq analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	human atherosclerotic plaque s	proposed	N/A
Sevoflurane-induced neurotoxicity (SIN) model in rats	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
Machine learning-based identification of C1Q hub genes	exploratory	Atherosclerosis	0.900	Human bulk RNA sequencing data	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	1-month-old APP/PS1 mice cereb	proposed	N/A
Gene expression validation in apoE-/- mice	validation	Atherosclerosis	0.850	apoE-/- mice	proposed	N/A
ox-LDL treatment of RAW264.7 macrophages	exploratory	Atherosclerosis	0.850	RAW264.7 macrophages	proposed	N/A
bEV-mediated synaptic pruning via C1q-C3 pathway	exploratory	Alzheimer's disease	0.850	microglia and synapses (in viv	proposed	N/A
Validation of hub genes in ox-LDL treated RAW264.7 macrophages	exploratory	Atherosclerosis	0.800	RAW264.7 macrophages	proposed	N/A
Validation of hub genes in apoE-/- atherosclerotic mice	validation	Atherosclerosis	0.800	apoE-/- mice	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995]	Petrisko TJ, Chu SH, Gomez-Arboledas A,	bioRxiv : the preprint server	2025	1
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-med [PMID:40731189]	Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S,	Alzheimer's & dementia : the j	2025	1
Trigeminal neuralgia. [PMID:38816415]	Ashina S, Robertson CE, Srikiatkhachorn	Nature reviews. Disease primer	2024	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138]	Gomez-Arboledas A, Acharya MM, Tenner AJ	ImmunoTargets and therapy	2021	1
Early complement genes are associated with visual system degeneration in multipl [PMID:31289819]	Fitzgerald KC, Kim K, Smith MD, Aston SA	Brain	2019	1
Opioid Receptors. [PMID:26332001]	Stein C	Annual review of medicine	2016	1
Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964]	Righes Marafiga J, Vu T, Bowlus J, Barab	Progress in neurobiology	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	Geroscience	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	GeroScience	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
Sex-Specific Molecular Architecture of Microglia-Mediated Neuronal Pruning Acros [PMID:41324815]	Sanfilippo C, Castrogiovanni P, Imbesi R	Molecular neurobiology	2025	0
Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649]	Griggs M, Daylor V, Petrucci T, Weintrau	ImmunoHorizons	2025	0
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007]	Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ,	Journal of neuroinflammation	2024	0
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. [PMID:35990663]	["Feng C", "Shan M", "Xia Y", "Zheng Z",	Frontiers in immunology	2022	0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022	0
Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217]	Figueroa CA, Aguilera A, Chakraborty B,	Journal of the American Medica	2021	0
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021	0

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning SYNAPTIC PRUNING in their description or question text

Microglial TREM2 Activation to Enhance Synaptic Pruning Regulation

Score: 0.510 · connectomics · 2026-04-25