gene

SIGLEC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGLEC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

1Analyses

0Outgoing

2Incoming

0Experiments

1Debates

Summary

SIGLEC3 (CD33) is a sialic acid-binding immunoglobulin-like lectin expressed primarily on microglia. It modulates neuroinflammation and phagocytosis in the brain, with genetic variants influencing Alzheimer's disease risk.

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🧬 Gene Info

Gene Symbol	SIGLEC3
Chromosome	19q13.41
Function	is a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family of cell surface receptors[@crocker2012].
Amino Acids	382 aa
Exons	7
Ensembl ID	ENSG00000105383
GeneCards	SIGLEC3
Human Protein Atlas	SIGLEC3
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SIGLEC3 Gene (CD33)

gene · 1592 words

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Pathway Diagram

graph TD
    SIGLEC3["SIGLEC3"]
    neurodegeneration["neurodegeneration"]
    SIGLEC3 -->|"implicated_in"| neurodegeneration
    style SIGLEC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (2)

Source	Relation	Type	Str
C1QA	engages	protein	0.70
C1QA	binds	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-21 | 1 hypotheses Top: 0.582

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-21

Related Research

Hypotheses and analyses mentioning SIGLEC3 in their description or question text

No additional research found