gene

apbb1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about apbb1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

22Outgoing

9Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	APBB1
Full Name	Amyloid Precursor Protein Binding Family B Member 1
Chromosome	11p15.4
Protein Type	Adaptor Protein
Function	APBB1 (Amyloid Precursor Protein Binding Family B Member 1), also known as Fe65, is a neuronal adaptor protein that plays critical roles in APP (Amyloid Precursor Protein) processing and signaling.
Primary Expression	the brain, particularly in: - Cerebral cortex (neurons) - Hippocampus (especially CA1 region) -
Molecular Weight	90 kDa
UniProt ID	[Q9UKP3](https://www.uniprot.org/uniprot/Q9UKP3)
Ensembl ID	ENSG00000196913
OMIM	602294
GeneCards	APBB1
Human Protein Atlas	APBB1
WW Domain	Mediates protein-protein interactions
PTB Domain	Binds to the cytoplasmic tail of APP
Transcriptional Activation Domain	Interacts with nuclear proteins
Associated Diseases	ALS, Diabetes, Hypertension
Interactions	Amyloid
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APBB1

gene · 554 words

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Pathway Diagram

graph TD
    APBB1["APBB1"]
    APBB1 -->|"regulates"| Alzheimer["Alzheimer"]
    APBB1 -->|"activates"| Als["Als"]
    APBB1 -->|"activates"| Diabetes["Diabetes"]
    APBB1 -->|"causes"| Hypertension["Hypertension"]
    APBB1 -->|"causes"| ALS["ALS"]
    APBB1 -->|"regulates"| FN1["FN1"]
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| APBB1
    APP["APP"] -->|"regulates"| APBB1
    CLU["CLU"] -->|"regulates"| APBB1
    CST3["CST3"] -->|"regulates"| APBB1
    GENES["GENES"] -->|"regulates"| APBB1
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"causes"| APBB1
    C1QA["C1QA"] -->|"regulates"| APBB1
    FN1 -->|"regulates"| APBB1

Outgoing (22)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APBB1	data_in	dataset_row	0.00
Diabetes	causes	disease	0.65
Alzheimer	regulates	disease	0.65
Hypertension	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	causes	disease	0.65
Hypertension	causes	disease	0.65
FN1	regulates	gene	0.60
AND	causes	gene	0.60
AMYLOID	causes	gene	0.60
DIABETES MELLITUS	causes	gene	0.60
Amyloid	causes	pathway	0.60
Amyloid	activates	protein	0.60
C1QA	regulates	gene	0.60
CST3	regulates	gene	0.60
CLU	regulates	gene	0.60
App	regulates	protein	0.60
Hippocampus	expressed_in	brain_region	0.55
C1QA	regulates	gene	0.50
ALZHEIMER	regulates	gene	0.50
CST3	regulates	gene	0.50

Incoming (9)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APBB1	data_in	dataset_row	0.00
GENES	regulates	gene	0.60
ALZHEIMER DISEASE	causes	gene	0.60
FN1	regulates	gene	0.60
APP	regulates	gene	0.60
CLU	regulates	gene	0.60
CST3	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
C1QA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning apbb1 in their description or question text

No additional research found