gene

PLIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

7Experiments

1Debates

Summary

PLIN2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with ALS, Aging, Als. Connected to 248 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLIN2
Chromosome	9p22.1
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Lipid Storage: Promotes triglyceride storage by facilitating lipid droplet formation and preventing lipolysis [@brasaemle2004]
Mechanism of Action	Direct PLIN2 inhibitors would reduce lipid droplet formation and stability, promoting lipid mobilization and reducing pathological lipid accumulation. Indirect approaches target upstream regulators of PLIN2 expression or modulate associated lipases to alter lipid storage dynamics in metabolic and neurodegenerative disease states.
Druggability	Undruggable (0.23)
Clinical Stage	Approved
Molecular Weight	46 kDa
Amino Acids	437 aa
Pathways	Ferroptosis, Lipid Metabolism, Mitochondrial Function
UniProt ID	Q99541
NCBI Gene ID	107
Ensembl ID	ENSG00000147872
GeneCards	PLIN2
Human Protein Atlas	PLIN2
Associated Diseases	Aging, ALS, Alzheimer, dementia, Lipid Droplet Accumulation
Known Drugs/Compounds	rapamycin, riluzole
Interactions	ABCA1, ACOX1, Actin, Adiponectin, ADIPOQ, ALS
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Metabolic Circuit Breaker via Lipid Droplet Modula
KG Connections	610 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLIN2 — AlphaFold Q99541 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PLIN2 Gene

gene · 1479 words

→

PLIN2 Protein

protein · 526 words

→

Pathway Diagram

flowchart TD
    PLIN2["PLIN2
Perilipin 2"]
    
    LD["Lipid Droplets
Formation"]
    LM["Lipid Metabolism
Pathway"]
    CHOL["Cholesterol
Pathway"]
    NR1H3["NR1H3
Liver X Receptor alpha"]
    
    APOP["Apoptosis
Pathway"]
    GLYC["Glycolysis
Pathway"]
    
    AD["Alzheimer's
Disease"]
    PD["Parkinson's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    NEURO["Neurodegeneration
Process"]
    
    AGING["Cellular
Aging"]
    SENES["Cellular
Senescence"]
    
    PLIN2 -->|"biomarker for"| LD
    PLIN2 -->|"expressed in"| LM
    PLIN2 -->|"expressed in"| CHOL
    PLIN2 -->|"activates"| LM
    PLIN2 -->|"activates"| NR1H3
    
    PLIN2 -->|"activates"| APOP
    PLIN2 -->|"activates"| GLYC
    
    PLIN2 -->|"regulates"| AD
    PLIN2 -->|"associated with"| PD
    PLIN2 -->|"regulates"| ALS
    PLIN2 -->|"regulates"| MS
    PLIN2 -->|"associated with"| NEURO
    
    PLIN2 -->|"regulates"| AGING
    PLIN2 -->|"associated with"| SENES
    
    style PLIN2 fill:#006494
    style LD fill:#1b5e20
    style LM fill:#1b5e20
    style CHOL fill:#1b5e20
    style NR1H3 fill:#4a1a6b
    style APOP fill:#ef5350
    style GLYC fill:#1b5e20
    style AD fill:#5d4400
    style PD fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style NEURO fill:#ef5350
    style AGING fill:#5d4400
    style SENES fill:#ef5350

Outgoing (391)

Target	Relation	Type	Str
Lipolysis	regulates	process	0.95
LIPID DROPLETS	regulates	entity	0.95
Lipid Droplet Metabolism	regulates	process	0.95
Lipid Droplet Regulation	regulates	process	0.95
Lipid Droplets	associated_with	cell_type	0.92
Lipid Droplet Formation	involved_in	process	0.90
LIPID METABOLISM	regulates	entity	0.90
Cell Differentiation	involved_in	process	0.90
lipid droplet metabolism	associated_with	process	0.90
CPT1A	binds_to	entity	0.90
Lipid Droplets	regulates	process	0.90
CELLULAR SENESCENCE	associated_with	entity	0.90
Major Adverse Cardiovascular Events	biomarker_for	phenotype	0.90
Blastocyst Formation	involved_in	process	0.90
Lipid Droplet-Mitochondria Tethering	promotes	process	0.90
CELL ENERGY STATE	regulates	entity	0.85
Lipid Droplet Accumulation	associated_with	phenotype	0.85
LIPID DROPLET STORAGE	regulates	entity	0.85
Intracellular Lipid Droplets	biomarker_for	phenotype	0.85
Cellular Senescence	biomarker_for	phenotype	0.85
Lipid Droplet Accumulation	regulates	process	0.85
Plin2 Expression	regulates	phenotype	0.80
Lipid Droplet	regulates	biological_process	0.80
Cell Energy State Maintenance	regulates	process	0.80
neurodegeneration	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
lipid droplets	biomarker_for	process	0.70
macrophages	expressed_in	cell_type	0.70
GENES	regulates	gene	0.70
Lipid Metabolism	regulates	pathway	0.70
unfolded protein response	participates_in	pathway	0.70
Cholesterol	associated_with	pathway	0.70
LIPOPHAGY	associated_with	gene	0.70
Dementia	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Senescence	associated_with	disease	0.65
Ms	activates	disease	0.65
Ms	causes	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Obesity	activates	disease	0.65
Ms	regulates	disease	0.65
Anxiety	activates	disease	0.65

Incoming (219)

Source	Relation	Type	Str
Chaperone-Mediated Autophagy	degrades	process	0.95
PFKL	phosphorylates	entity	0.95
PFKL	interacts_with	entity	0.90
NM1	upregulates	protein	0.90
h-3d993b5d	targets	hypothesis	0.90
CRISPR-Cas9	targets	entity	0.90
Genetic Modifiers	regulates	mechanism	0.90
Crispr-Cas9	targets	mechanism	0.85
MYO1C	upregulates	gene	0.85
YAP	downregulates	gene	0.85
Mi-891	downregulates	drug	0.80
Hypoxia	upregulates	process	0.80
SPP1	upregulates	gene	0.75
BAX	inhibits	gene	0.60
APOA1	regulates	entity	0.60
CD36	regulates	entity	0.60
DGAT1	regulates	entity	0.60
NR1H3	regulates	entity	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
GRK2	activates	entity	0.60
HTRA2	activates	entity	0.60
KDM6B	activates	entity	0.60
LC3	activates	entity	0.60
MAP3K5	activates	entity	0.60
NFE2L2	activates	entity	0.60
NOS3	activates	entity	0.60
P62	activates	entity	0.60
GBA	causes	gene	0.60
IL6	targets	gene	0.60
DGAT1	activates	gene	0.60
APOA1	activates	gene	0.60
CD36	activates	gene	0.60
JUN	activates	gene	0.60
GBA	associated_with	gene	0.60
GCASE	causes	gene	0.60
LAMP1	activates	gene	0.60
ATG5	activates	gene	0.60
APOE	activates	gene	0.60
BECN1	regulates	gene	0.60
C1Q	regulates	gene	0.60
FOXO1	regulates	gene	0.60
GLP1R	regulates	gene	0.60
LC3	regulates	gene	0.60
MTOR	regulates	gene	0.60
ATG5	biomarker_for	gene	0.60
BECN1	biomarker_for	gene	0.60
LAMP1	biomarker_for	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabolic Circuit Breaker via Lipid Droplet Modulation	0.709	neurodegeneration	Microglia-astrocyte crosstalk amplificat
PLIN2 (Perilipin-2) Degradation via Autophagy Activation to	0.535	lipidomics	Lipid metabolism dysregulation in Alzhei

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729

Experiments (7)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Microglia activate astrocytes via I	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Metabolic Pathway-Targeted Therapy in ALS	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Cytochrome Therapeutics	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Peroxisomal Dysfunction Validation in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Peroxisome Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria [PMID:38773347]	Meng Y, Guo D, Lin L, Zhao H, Xu W, Luo	Nat Metab	2024	1
Lipid accumulation drives cellular senescence in dopaminergic neurons. [PMID:39033779]	Russo T, Riessland M	Aging (Albany NY)	2024	1
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regu [PMID:37494933]	Roberts MA, Deol KK, Mathiowetz AJ, Lang	Dev Cell	2023	1
Comprehensive single-cell transcriptional profiling defines shared and unique ep [PMID:36265491]	Li H, Dixon EE, Wu H, Humphreys BD	Cell Metab	2022	1
Novel mechanisms of dietary folic acid in improving hepatopancreas health of gra [PMID:41871815]	Wang Y, Feng L, Dan Jiang W, Wu P, Liu Y	The Journal of nutritional bio	2026	0
African swine fever virus hijacks lipolysis induced by chaperone-mediated autoph [PMID:41801037]	["Yang X", "Xiong X", "Liu H", "Wen X",	mBio	2026	0
Carotid plaque macrophage burden and inflammatory lipid-associated macrophage ma [PMID:41758068]	["Prange K", "Bel-Bordes G", "Depuydt M"	European heart journal	2026	0
Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replic [PMID:41810751]	["Yang M", "Chen J", "Su X", "Kan X", "T	Autophagy	2026	0
Epithelial-Mesenchymal Transition Shapes the Lipotoxic Response of Colon Cancer [PMID:41831570]	Vari F, Serra I, Bisconti E, Stanca E, R	Molecular & cellular proteomic	2026	0
Serum Perilipin-2 as a Novel Biomarker for Obstructive Sleep Apnea: Association [PMID:41827192]	Sagcan G, Uzun H	Journal of clinical medicine	2026	0
PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/H [PMID:41888110]	Celada L, Cubiella T, San-Juan-Guardado	Cell death & disease	2026	0
Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862]	Wang B, Li Y, Wang Y, Chen J, Wang J et	Animals (Basel)	2026	0
Integrated Analysis of Metabolomics and Proteomics Reveals the Potential Mechani [PMID:41841177]	["Wu S", "Wang B", "Zhang N", "Feng C",	Journal of applied toxicology	2026	0
Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. [PMID:41376284]	Xie XY, Wang L, Xie SQ, Zhou GF, Wen QX,	Autophagy	2026	0
Analysis of high glucose injury using human induced pluripotent stem cell-derive [PMID:41507800]	["Qian Z", "Yang D", "Li Y", "Dong R", "	BMC nephrology	2026	0
Pregnane X receptor antagonist MI-891 reduces hepatic triglycerides in PXR-CAR-C [PMID:41795330]	["Dohnalov\u00e1 K", "Kamaraj R", "Ambro	Biomedicine & pharmacotherapy	2026	0
Nuclear Myosin 1 links genomic architecture to adipose tissue remodeling, metabo [PMID:41748556]	["Khalaji S", "Venit T", "Luk\u00e1\u010	Cell death & disease	2026	0
Benzo[a]pyrene exacerbates atherosclerosis by upregulating SPP1 to promote macro [PMID:41747816]	["Li R", "Zheng J", "Tang Y", "Liu A", "	Vascular pharmacology	2026	0
Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862]	Wang B, Li Y, Wang Y, Chen J, Wang J, Li	Animals : an open access journ	2026	0
Repurposing daclatasvir for MASLD Therapy-A promising step forward with challeng [PMID:40617356]	["Pirola C"]	Journal of lipid research	2025	0

Debates (1)

Multi-agent debates referencing this entity

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning PLIN2 in their description or question text

No additional research found