Contents

PLIN2 Gene

🧬 Gene Info

Gene Symbol	PLIN2
Chromosome	9p22.1
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Lipid Storage: Promotes triglyceride storage by facilitating lipid droplet formation and preventing lipolysis [@brasaemle2004]
Mechanism of Action	Direct PLIN2 inhibitors would reduce lipid droplet formation and stability, promoting lipid mobilization and reducing pathological lipid accumulation. Indirect approaches target upstream regulators of PLIN2 expression or modulate associated lipases to alter lipid storage dynamics in metabolic and neurodegenerative disease states.
Druggability	Undruggable (0.23)
Clinical Stage	Approved
Molecular Weight	46 kDa
Amino Acids	437 aa
Pathways	Ferroptosis, Lipid Metabolism, Mitochondrial Function
UniProt ID	Q99541
NCBI Gene ID	107
Ensembl ID	ENSG00000147872
GeneCards	PLIN2
Human Protein Atlas	PLIN2
Associated Diseases	Aging, ALS, Alzheimer, dementia, Lipid Droplet Accumulation
Known Drugs/Compounds	rapamycin, riluzole
Interactions	ABCA1, ACOX1, Actin, Adiponectin, ADIPOQ, ALS
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Metabolic Circuit Breaker via Lipid Droplet Modula
KG Connections	610 knowledge graph edges
Databases	GeneCards HPA STRING

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