concept

CELLULAR SENESCENCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELLULAR SENESCENCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

312Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

10Debates

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💡 Concept Info

Name	CELLULAR SENESCENCE

Pathway Diagram

graph TD
    CELLULAR_SENESCENCE["CELLULAR SENESCENCE"]
    style CELLULAR_SENESCENCE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CELLULAR_SENESCENCE -->|"involved_in"| Cardiac_Aging["Cardiac Aging"]
    CELLULAR_SENESCENCE -->|"causes"| Cell_Cycle_Arrest(Cell Cycle Arrest)
    CELLULAR_SENESCENCE -->|"causes"| Apoptosis_Resistance(Apoptosis Resistance)
    CELLULAR_SENESCENCE -->|"causes"| Senescence_Associated_Secretor(Senescence-Associated Secretory Phenotype)
    CELLULAR_SENESCENCE -->|"causes"| cell_cycle_arrest(cell cycle arrest)
    CELLULAR_SENESCENCE -->|"promotes"| pro_inflammatory_molecules["pro-inflammatory molecules"]
    CELLULAR_SENESCENCE -->|"expressed in"| Dopaminergic_Neurons["/Dopaminergic Neurons/"]
    CELLULAR_SENESCENCE -->|"mediates"| Senescence_Associated_Secretom["Senescence-Associated Secretome"]
    CELLULAR_SENESCENCE -->|"involved_in"| Biological_Aging["Biological Aging"]
    CELLULAR_SENESCENCE -->|"contributes to"| Aging["Aging"]
    Lipid_Accumulation["Lipid Accumulation"] -->|"causes"| CELLULAR_SENESCENCE
    AMPK([AMPK]) -->|"regulates"| CELLULAR_SENESCENCE
    LIPID_ACCUMULATION["LIPID ACCUMULATION"] -->|"causes"| CELLULAR_SENESCENCE
    Telomere_Dysfunction["Telomere Dysfunction"] -->|"causes"| CELLULAR_SENESCENCE
    PGAM5([PGAM5]) -->|"modulates"| CELLULAR_SENESCENCE
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"causes"| CELLULAR_SENESCENCE
    P53([P53]) -->|"promotes"| CELLULAR_SENESCENCE
    cGAS_STING["cGAS/STING"] -->|"regulates"| CELLULAR_SENESCENCE
    cGAS_STING_signaling_pathway["cGAS/STING signaling pathway"] -->|"regulates"| CELLULAR_SENESCENCE
    Ginkgetin{"Ginkgetin"} -.->|"prevents"| CELLULAR_SENESCENCE

Outgoing (84)

Target	Relation	Type	Str
Apoptosis Resistance	causes	phenotype	0.95
Cell Cycle Arrest	causes	phenotype	0.95
DOPAMINERGIC NEURONS	associated_with	entity	0.95
aging	associated_with	process	0.95
Senescence-Associated Secretory Phenotype	causes	phenotype	0.95
Cardiac Aging	involved_in	process	0.95
Inflammation	promotes	process	0.95
Alzheimer Disease	contributes_to	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
ALZHEIMER'S DISEASE	causes	disease	0.95
PARKINSON'S DISEASE	causes	disease	0.95
senescence-associated secretory phenotype	drives	phenotype	0.95
pro-inflammatory molecules	promotes	pathway	0.95
cell cycle arrest	causes	phenotype	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Neurodegeneration	associated_with	disease	0.95
Alzheimer'S Disease Pathology	mediates	mechanism	0.92
AGING	associated_with	process	0.90
Dopaminergic Neurons	expressed_in	cell_type	0.90
Neurodegenerative Diseases	contributes_to	disease	0.90
NEURODEGENERATION	contributes_to	process	0.90
Neuroinflammation	promotes	process	0.90
senescence-related disorders	causes	disease	0.90
Senescence-Associated Secretome	mediates	pathway	0.90
Cellular Dysfunction	contributes_to	phenotype	0.90
neurodegenerative disorders	contributes_to	disease	0.90
Aging	associated_with	process	0.90
Biological Aging	involved_in	process	0.90
Chronic Aging-Related Diseases	contributes_to	disease	0.90
Senescence Biomarkers	biomarker_for	biomarker	0.90
Chronic Inflammation	contributes_to	process	0.90
Biological Aging	mediates	process	0.90
Senescence-Associated Secretory Phenotype	mediates	phenotype	0.90
Senescence-Associated Secretory Phenotype	associated_with	phenotype	0.90
Neuroinflammation	contributes_to	process	0.90
Embryonic Development	involved_in	process	0.90
Wound Healing	involved_in	process	0.90
Inflammation	causes	process	0.90
Obesity	associated_with	disease	0.90
Inflammaging	associated_with	process	0.90
Cognitive Deficits	causes	phenotype	0.88
Osteoarthritis	contributes_to	disease	0.88
Myocardial Ischemia And Infarction	involved_in	disease	0.87
Apoptosis	associated_with	process	0.85
Brain Aging	involved_in	process	0.85
Neurodegenerative Disease	associated_with	disease	0.85
Myocardial Infarction	involved_in	disease	0.85
Heart Failure	involved_in	disease	0.85
Myocardial Ischemia	involved_in	disease	0.85
Myocardial Ischemia and Infarction	involved_in	disease	0.85

Incoming (228)

Source	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.95
cGAS/STING	regulates	pathway	0.95
Telomere Dysfunction	causes	mechanism	0.95
Mir-302B	associated_with	biomarker	0.95
PGAM5	modulates	protein	0.95
Mitochondrial Dysfunction	causes	process	0.95
LIPID ACCUMULATION	causes	entity	0.95
Ginkgetin	inhibits	compound	0.95
P53	promotes	protein	0.95
MIR-302B	associated_with	gene	0.95
Ginkgetin	associated_with	compound	0.95
cGAS/STING signaling pathway	regulates	pathway	0.95
Lipid Accumulation	promotes	process	0.95
Dasatinib	inhibits	drug	0.95
AMPK	regulates	protein	0.95
aging	drives	process	0.95
Quercetin	inhibits	compound	0.95
Lipid Accumulation	causes	process	0.95
Cgas/Sting Signaling	regulates	pathway	0.95
SRT2104	suppresses	drug	0.93
Ginkgetin	prevents	drug	0.92
STING	regulates	protein	0.92
BHB	suppresses	compound	0.90
CDKN2A	associated_with	protein	0.90
CDKN1A	associated_with	protein	0.90
41101499	is a hallmark of	paper	0.90
Obesity	associated_with	phenotype	0.90
autophagy	suppresses	process	0.90
41101499	delay	paper	0.90
MTOR	involved_in	gene	0.90
41101499	drives	paper	0.90
SDA-2026-04-01-gap-013	investigates	analysis	0.90
SIRT1	regulates	gene	0.90
Prediabetes	associated_with	disease	0.90
Microglia	involved_in	cell_type	0.90
mitophagy	protects_against	process	0.90
iPSC Reprogramming	associated_with	process	0.90
PLIN2	associated_with	entity	0.90
IL23R	biomarker_for	protein	0.90
Partial Reprogramming	associated_with	process	0.90
Lysosomal Impairment	associated_with	process	0.90
Metabolic Reprogramming	associated_with	process	0.90
H₂O₂	causes	compound	0.90
apoptosis resistance	associated_with	phenotype	0.90
senolytics	targets	drug	0.90
SQSTM1	prevents	gene	0.90
Intermittent Fasting	modulates	drug	0.90
Astrocytes	involved_in	cell_type	0.90
lipid accumulation	drives	process	0.90
oncogene-induced stress	causes	process	0.90

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop neuromodulation-inspired cytokine axis suppressi	0.530	cell biology	-
P2RY12 activation induces cellular senescence in cerebral VS	0.373	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio