concept

PRION-LIKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRION-LIKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

2Hypotheses

0Analyses

10Outgoing

31Incoming

10Experiments

0Debates

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💡 Concept Info

Name	PRION-LIKE

Pathway Diagram

graph TD
    PRION_LIKE["PRION-LIKE"]
    BRAINSTEM["BRAINSTEM"] -->|"reduces"| PRION_LIKE
    NEURON["NEURON"] -->|"causes"| PRION_LIKE
    LEWY_BODY["LEWY BODY"] -->|"causes"| PRION_LIKE
    NEURODEGENERATION["NEURODEGENERATION"] -->|"causes"| PRION_LIKE
    AMYLOID["AMYLOID"] -->|"contributes to"| PRION_LIKE
    FUS["FUS"] -->|"mediates"| PRION_LIKE
    HUNTINGTON["HUNTINGTON"] -->|"mediates"| PRION_LIKE
    HUNTINGTON_S["HUNTINGTON'S"] -->|"mediates"| PRION_LIKE

Outgoing (10)

Target	Relation	Type	Str
SOD1	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
SEEDING	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
TAU PROPAGATION	co_discussed	entity	0.50
TARDBP	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
SQSTM1	co_discussed	entity	0.50
SNCA	co_discussed	entity	0.50

Incoming (31)

Source	Relation	Type	Str
NEURON	co_discussed	entity	0.50
BRAINSTEM	co_discussed	entity	0.50
ALPHA-SYNUCLEIN	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
GLYMPHATIC	co_discussed	entity	0.50
INTERNEURON	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
C9ORF72	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
NEURONS	co_discussed	cell_type	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
GLUTAMATE	co_discussed	entity	0.50
FRONTOTEMPORAL	co_discussed	entity	0.50
FTD	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
MAPT	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
FUS	co_discussed	entity	0.50
HUNTINGTON	co_discussed	entity	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Enteric Nervous System Prion-Like Propagation Blockade	0.480	neurodegeneration	What are the mechanisms by which gut mic
Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa	0.440	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiation Mechanis	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Computational Modeling of Alpha-Synuclein Propagation in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Alpha-Synuclein Seed Amplification Assay Validation	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation and Neuro	exploratory	Parkinson's Disease	0.400	0.50	human	proposed	$2,070,000
Antiviral Therapy Trial for Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Map	validation	Parkinson's Disease	0.400	0.50	cell_line	proposed	$160,000
Genetic Risk Modifiers in DLB Phenotype	clinical	Neurodegeneration	0.400	0.50	human	proposed	$7,500,000
Tau Co-Pathology in DLB Clinical Heterogeneity	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symp [PMID:36965781]	["Ishola IO", "Awogbindin IO", "Olubodun	Neurotoxicology	2023	1
Toll-like receptor expression in the blood and brain of patients and a mouse mod [PMID:25522431]	Drouin-Ouellet J, St-Amour I, Saint-Pier	The international journal of n	2014	1
The Gut-Brain Axis Based on α-Synuclein Propagation-Clinical, Neuropatholo [PMID:40362234]	Unknown	International journal of molec	2025	0
Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeut [PMID:41465422]	Ahremenko E, Andreev A, Apushkin D, Kork	International journal of molec	2025	0
Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated [PMID:40554107]	["Zeng H", "Qi J", "Chen Q", "Zhang R",	Ecotoxicology and environmenta	2025	0
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024	0
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431]	Wang W, Wang Y, Wang F, Xie G, Liu S, Li	Phytomedicine : international	2024	0
Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflamm [PMID:39117089]	["Panda S", "Kesharwani A", "Singh M", "	Fitoterapia	2024	0
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023	0
The role of the microbiota in glaucoma. [PMID:37866106]	Huang L, Hong Y, Fu X, Tan H, Chen Y, Wa	Molecular aspects of medicine	2023	0
Melatonin mitigates aflatoxin B1-induced liver injury via modulation of gut micr [PMID:35652241]	["Liu S", "Kang W", "Mao X", "Ge L", "Du	Journal of pineal research	2022	0
Contriving multi-epitope vaccine ensemble for monkeypox disease using an immunoi [PMID:36311762]	["Aziz S", "Almajhdi F", "Waqas M", "Ull	Frontiers in immunology	2022	0
Galectin-3, a rising star in modulating microglia activation under conditions of [PMID:35859075]	["Garc\u00eda-Revilla J", "Boza-Serrano	Cell death & disease	2022	0
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory [PMID:35989519]	Sawamura M, Onoe H, Tsukada H	Mov Disord	2022	0
Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disea [PMID:34043864]	Unknown	The European journal of neuros	2021	0
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocyt [PMID:31790685]	["Wu S", "Zhao M", "Sun Y", "Xie M", "Le	Life sciences	2020	0
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020	0
Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation. [PMID:32087283]	Yang L, Zhou R, Tong Y, Chen P, Shen Y,	Neurobiology of disease	2020	0
Synucleinphagy: a microglial "community cleanup program" for neuroprotection. [PMID:32453651]	["Choi I", "Seegobin S", "Liang D", "Yue	Autophagy	2020	0
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-in [PMID:31628991]	Mezias C, Rey N, Brundin P	Neurobiol Dis	2020	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRION-LIKE in their description or question text

No additional research found