concept

P21

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

679Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

P21 is a concept in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Aging, Als. Connected to 289 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	P21
Key Genes/Proteins	ACTB, Actin, ADNP, AGING, AIF, AKT
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

NUP214 — Nucleoporin 214

gene · 1172 words

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Pathway Diagram

graph TD
    P21["P21"]
    P21 -->|"activates"| senescence["senescence"]
    P21 -->|"regulates"| cellular_senescence["cellular senescence"]
    P21 -->|"activates"| Aging["Aging"]
    P21 -->|"regulates"| ALS["ALS"]
    P21 -->|"inhibits"| Senescence["Senescence"]
    P21 -->|"regulates"| Inflammation["Inflammation"]
    P21 -->|"inhibits"| Tumor["Tumor"]
    P21 -->|"inhibits"| Cancer["Cancer"]
    P21 -->|"activates"| Ms["Ms"]
    P21 -->|"activates"| Als["Als"]
    P21 -->|"activates"| Depression["Depression"]
    PRDM4["PRDM4"] -->|"upregulates"| P21
    PRKCH["PRKCH"] -->|"regulates"| P21
    APOPTOSIS["APOPTOSIS"] -->|"activates"| P21
    AND["AND"] -->|"activates"| P21
    TERC["TERC"] -->|"regulates"| P21
    GENES["GENES"] -->|"regulates"| P21
    CYTOKINES["CYTOKINES"] -->|"regulates"| P21
    DNA["DNA"] -->|"inhibits"| P21
    AMPK["AMPK"] -->|"activates"| P21
    ATP["ATP"] -->|"activates"| P21
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| P21

Outgoing (376)

Target	Relation	Type	Str
Aging	activates	disease	1.00
Als	activates	disease	1.00
Oxidative Stress	activates	pathway	0.90
Tumor	activates	disease	0.85
Senescence	activates	disease	0.85
Cancer	activates	disease	0.85
Senescence	regulates	disease	0.85
senescence	activates	pathway	0.80
senescent cells	expressed_in	cell_type	0.80
BCL-2	upstream_of	protein	0.80
Apoptosis	activates	pathway	0.80
Cell Cycle	activates	pathway	0.80
Lung Cancer	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	expressed_in	disease	0.75
Inflammation	regulates	disease	0.75
Tumor	inhibits	disease	0.75
Mtor	regulates	pathway	0.70
Cell Cycle	inhibits	pathway	0.70
MTOR	regulates	gene	0.70
cellular senescence	regulates	process	0.70
Carcinoma	therapeutic_target	disease	0.65
Viral Infection	activates	disease	0.65
Osteoarthritis	treats	disease	0.65
Aging	therapeutic_target	disease	0.65
Infection	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Inflammation	biomarker_for	disease	0.65
Tumor	regulates	disease	0.65
Stroke	regulates	disease	0.65
Longevity	activates	disease	0.65
Sarcopenia	treats	disease	0.65
Inflammation	activates	disease	0.65
Depression	activates	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Aging	treats	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
ALS	regulates	disease	0.65
Ms	activates	disease	0.65
Senescence	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Als	treats	disease	0.65

Incoming (303)

Source	Relation	Type	Str
P53	regulates	gene	1.00
AGING	activates	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
Polygonatum sibiricum polysaccharide	downregulates	compound	0.85
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.80
PRDM4	upregulates	gene	0.80
CANCER	activates	gene	0.80
P53	inhibits	gene	0.80
P53	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
GENES	expressed_in	gene	0.80
DNA	activates	gene	0.80
CANCER	expressed_in	gene	0.70
SQSTM1	regulates	gene	0.70
P62	regulates	gene	0.70
P16	regulates	gene	0.70
GAL	activates	gene	0.70
GENES	regulates	gene	0.70
PRKCH	regulates	gene	0.70
AMPK	activates	gene	0.70
BAX	expressed_in	gene	0.70
CDKN1A	inhibits	gene	0.70
GENES	inhibits	gene	0.70
BCL-2	expressed_in	gene	0.70
CANCER	therapeutic_target	gene	0.70
ATG16L1	activates	gene	0.60
PI3K	activates	gene	0.60
ATG5	activates	gene	0.60
CYP2E1	activates	gene	0.60
CANCER	contributes_to	gene	0.60
PAK1	activates	gene	0.60
DNA	inhibits	gene	0.60
ROS	therapeutic_target	gene	0.60
RB1	contributes_to	gene	0.60
P16	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GBM	activates	gene	0.60
P16	activates	gene	0.60
AKT	activates	gene	0.60
ERK	regulates	gene	0.60
MDM2	contributes_to	gene	0.60
ATG5	inhibits	gene	0.60
CYCLIN D1	contributes_to	gene	0.60
ERK	activates	gene	0.60
BECN1	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
EGF	activates	gene	0.60
AKT	regulates	gene	0.60
TSC1	regulates	gene	0.60
GAPDH	inhibits	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor	0.710	molecular biology	What is the optimal therapeutic window t
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.564	neuroinflammation	What molecular mechanisms drive the tran
Nucleolar p21-rRNA Co-Aggregation as Irreversible Senescence	0.500	molecular biology	What is the optimal therapeutic window t

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 1.000

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning P21 in their description or question text

No additional research found

P21

Understanding Entity Pages

Summary

Wiki Pages (1)

NUP214 — Nucleoporin 214

Pathway Diagram

Outgoing (376)

Incoming (303)

Targeting Hypotheses (3)

Mentioning Analyses (1)

Senescent cell clearance as neurodegeneration therapy

Experiments (0)

Related Papers (0)

Debates (3)

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Senescent cell clearance as neurodegeneration therapy

Related Research