Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRKCH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PRKCH |
| Protein Type | Kinase |
| Function | is a member of the protein kinase C (PKC) family of serine/threonine kinases. |
| Primary Expression | various tissues including the brain, epithelial cells, and skin [@uniprot] |
| Subcellular Localization | in both neuronal cell bodies and synaptic terminals, suggesting roles in synapti |
| GeneCards | PRKCH |
| Human Protein Atlas | PRKCH |
| Cell Differentiation | PKCη promotes differentiation in various cell types, including keratinocytes and neuronal cells [@pkca] |
| Cell Proliferation | Regulates cell cycle progression and proliferation through multiple signaling pathways [@pkcb] |
| Signal Transduction | Participates in receptor-mediated signaling cascades involving DAG and phorbol esters [@pkc] |
| Neuronal Function | Expressed in neurons where it modulates synaptic plasticity and neuroprotective pathways [@protein] |
| Parkinson's Disease | Research suggests PKCη may play a role in dopaminergic neuron survival and alpha-synuclein aggregation pathways [@pkcc] |
| Cancer | PKCη is overexpressed in several cancers and is associated with tumor progression and metastasis [@pkcd] |
| Skin Disorders | Due to its role in keratinocyte differentiation, PKCη is implicated in psoriasis and other skin conditions [@pkc2004] |
| Associated Diseases | neurodegeneration |
| Interactions | MARCKS |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["PRKCH"]
N1["Runx2"]
N0 -->|"regulates"| N1
N2["ROCK1"]
N2 -->|"regulates"| N0
N3["PKC-eta"]
N3 -->|"regulates"| N0
N4["MARCKS"]
N0 -->|"phosphorylates"| N4
N5["p53"]
N0 -->|"regulates"| N5
N6["p21"]
N0 -->|"regulates"| N6
N7["neurodegeneration"]
N0 -->|"implicated in"| N7
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N2 gene
class N3 protein
class N4 protein
class N5 protein
class N6 proteinHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PRKCH in their description or question text
No additional research found