gene

PRDM4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

13Outgoing

2Incoming

0Experiments

0Debates

Summary

Comprehensive gene profile for PRDM4 (PR/SET Domain 4), a histone methyltransferase with roles in neural development, cognitive function, and neurodegenerative disease.

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🧬 Gene Info

Gene Symbol	PRDM4
Full Name	PR/SET Domain 4
Chromosome	12q23.3
Protein Family	PRDM (PRDI-BF1 and RIZ homology domain containing)
Protein Type	Transferase
Function	This activity is central to PRDM4's function as a transcriptional repressor.
Primary Expression	Brain (hippocampus, cortex), neural stem cells, testis, adrenal
Molecular Weight	68 kDa
Pathways	Notch, Wnt
UniProt ID	Q9Y5A9
NCBI Gene ID	9368
Ensembl ID	ENSG00000110635
OMIM	605346
GeneCards	PRDM4
Human Protein Atlas	PRDM4
Associated Diseases	neurodegeneration
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRDM4 — AlphaFold Q9Y5A9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRDM4 Gene

gene · 2143 words

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Pathway Diagram

graph TD
    PRDM4["PRDM4"]
    cell_proliferation["cell proliferation"]
    PRDM4 -->|"inhibits"| cell_proliferation
    gene_expression["gene expression"]
    PRDM4 -->|"regulates"| gene_expression
    p27["p27"]
    PRDM4 -->|"upregulates"| p27
    p21["p21"]
    PRDM4 -->|"upregulates"| p21
    HNRPA0["HNRPA0"]
    PRDM4 -->|"associated with"| HNRPA0
    neurodegeneration["neurodegeneration"]
    PRDM4 -->|"implicated in"| neurodegeneration
    NGF["NGF"]
    NGF -->|"downregulates"| PRDM4
    hsa_miR_373["hsa-miR-373"]
    hsa_miR_373 -->|"regulates"| PRDM4
    style PRDM4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
cell proliferation	inhibits	biological_process	0.90
gene expression	regulates	biological_process	0.80
p27	upregulates	gene	0.80
p21	upregulates	gene	0.80
HNRPA0	associated_with	gene	0.70
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
T Cell	regulates	cell_type	0.60
Rb	regulates	protein	0.60
Wnt	regulates	pathway	0.60
Notch	regulates	pathway	0.60
RARB	regulates	gene	0.60
Igf	regulates	protein	0.60

Incoming (2)

Source	Relation	Type	Str
hsa-miR-373	regulates	entity	0.70
RNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRDM4 in their description or question text

No additional research found